Cargando…
Computational Study of Correlated Domain Motions in the AcrB Efflux Transporter
As active part of the major efflux system in E. coli bacteria, AcrB is responsible for the uptake and pumping of toxic substrates from the periplasm toward the extracellular space. In combination with the channel protein TolC and membrane fusion protein AcrA, this efflux pump is able to help the bac...
Autores principales: | Schulz, Robert, Vargiu, Attilio V., Ruggerone, Paolo, Kleinekathöfer, Ulrich |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313061/ https://www.ncbi.nlm.nih.gov/pubmed/25685792 http://dx.doi.org/10.1155/2015/487298 |
Ejemplares similares
-
Functional Rotation of the Transporter AcrB: Insights into Drug Extrusion from Simulations
por: Schulz, Robert, et al.
Publicado: (2010) -
Molecular Interactions of Carbapenem Antibiotics with the Multidrug Efflux Transporter AcrB of Escherichia coli
por: Atzori, Alessio, et al.
Publicado: (2020) -
A framework for dissecting affinities of multidrug efflux transporter AcrB to fluoroquinolones
por: Vergalli, Julia, et al.
Publicado: (2022) -
Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump
por: Grimsey, Elizabeth M., et al.
Publicado: (2020) -
Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB
por: Reading, Eamonn, et al.
Publicado: (2020)