Prokineticin 2 Upregulation in the Peripheral Nervous System Has a Major Role in Triggering and Maintaining Neuropathic Pain in the Chronic Constriction Injury Model

The new chemokine Prokineticin 2 (PROK2) and its receptors (PKR(1) and PKR(2)) have a role in inflammatory pain and immunomodulation. Here we identified PROK2 as a critical mediator of neuropathic pain in the chronic constriction injury (CCI) of the sciatic nerve in mice and demonstrated that blocki...

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Detalles Bibliográficos
Autores principales: Lattanzi, Roberta, Maftei, Daniela, Marconi, Veronica, Florenzano, Fulvio, Franchi, Silvia, Borsani, Elisa, Rodella, Luigi Fabrizio, Balboni, Gianfranco, Salvadori, Severo, Sacerdote, Paola, Negri, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313068/
https://www.ncbi.nlm.nih.gov/pubmed/25685780
http://dx.doi.org/10.1155/2015/301292

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