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Antigenic properties and virulence of foot-and-mouth disease virus rescued from full-length cDNA clone of serotype O, typical vaccine strain
We cloned the full-length cDNA of O Manisa, the virus for vaccinating against foot-and-mouth disease. The antigenic properties of the virus recovered from the cDNA were similar to those of the parental virus. Pathogenesis did not appear in the pigs, dairy goats or suckling mice, but neutralizing ant...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Vaccine Society
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313104/ https://www.ncbi.nlm.nih.gov/pubmed/25648340 http://dx.doi.org/10.7774/cevr.2015.4.1.114 |
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author | Kim, Rae-Hyung Chu, Jia-Qi Park, Jeong-Nam Lee, Seo-Yong Lee, Yeo-Joo Ko, Mi-Kyeong Hwang, Ji-Hyeon Lee, Kwang-Nyeong Kim, Su-Mi Tark, Dongseob Ko, Young-Joon Lee, Hyang-Sim Seo, Min-Goo Park, Min-Eun Kim, Byounghan Park, Jong-Hyeon |
author_facet | Kim, Rae-Hyung Chu, Jia-Qi Park, Jeong-Nam Lee, Seo-Yong Lee, Yeo-Joo Ko, Mi-Kyeong Hwang, Ji-Hyeon Lee, Kwang-Nyeong Kim, Su-Mi Tark, Dongseob Ko, Young-Joon Lee, Hyang-Sim Seo, Min-Goo Park, Min-Eun Kim, Byounghan Park, Jong-Hyeon |
author_sort | Kim, Rae-Hyung |
collection | PubMed |
description | We cloned the full-length cDNA of O Manisa, the virus for vaccinating against foot-and-mouth disease. The antigenic properties of the virus recovered from the cDNA were similar to those of the parental virus. Pathogenesis did not appear in the pigs, dairy goats or suckling mice, but neutralizing antibodies were raised 5-6 days after the virus challenge. The utilization of O Manisa as a safe vaccine strain will increase if recombinant viruses can be manipulated by inserting or removing a marker gene for differential serology or replacing the protective gene from another serotype. |
format | Online Article Text |
id | pubmed-4313104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Vaccine Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-43131042015-02-03 Antigenic properties and virulence of foot-and-mouth disease virus rescued from full-length cDNA clone of serotype O, typical vaccine strain Kim, Rae-Hyung Chu, Jia-Qi Park, Jeong-Nam Lee, Seo-Yong Lee, Yeo-Joo Ko, Mi-Kyeong Hwang, Ji-Hyeon Lee, Kwang-Nyeong Kim, Su-Mi Tark, Dongseob Ko, Young-Joon Lee, Hyang-Sim Seo, Min-Goo Park, Min-Eun Kim, Byounghan Park, Jong-Hyeon Clin Exp Vaccine Res Brief Communication We cloned the full-length cDNA of O Manisa, the virus for vaccinating against foot-and-mouth disease. The antigenic properties of the virus recovered from the cDNA were similar to those of the parental virus. Pathogenesis did not appear in the pigs, dairy goats or suckling mice, but neutralizing antibodies were raised 5-6 days after the virus challenge. The utilization of O Manisa as a safe vaccine strain will increase if recombinant viruses can be manipulated by inserting or removing a marker gene for differential serology or replacing the protective gene from another serotype. The Korean Vaccine Society 2015-01 2015-01-30 /pmc/articles/PMC4313104/ /pubmed/25648340 http://dx.doi.org/10.7774/cevr.2015.4.1.114 Text en © Korean Vaccine Society. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Communication Kim, Rae-Hyung Chu, Jia-Qi Park, Jeong-Nam Lee, Seo-Yong Lee, Yeo-Joo Ko, Mi-Kyeong Hwang, Ji-Hyeon Lee, Kwang-Nyeong Kim, Su-Mi Tark, Dongseob Ko, Young-Joon Lee, Hyang-Sim Seo, Min-Goo Park, Min-Eun Kim, Byounghan Park, Jong-Hyeon Antigenic properties and virulence of foot-and-mouth disease virus rescued from full-length cDNA clone of serotype O, typical vaccine strain |
title | Antigenic properties and virulence of foot-and-mouth disease virus rescued from full-length cDNA clone of serotype O, typical vaccine strain |
title_full | Antigenic properties and virulence of foot-and-mouth disease virus rescued from full-length cDNA clone of serotype O, typical vaccine strain |
title_fullStr | Antigenic properties and virulence of foot-and-mouth disease virus rescued from full-length cDNA clone of serotype O, typical vaccine strain |
title_full_unstemmed | Antigenic properties and virulence of foot-and-mouth disease virus rescued from full-length cDNA clone of serotype O, typical vaccine strain |
title_short | Antigenic properties and virulence of foot-and-mouth disease virus rescued from full-length cDNA clone of serotype O, typical vaccine strain |
title_sort | antigenic properties and virulence of foot-and-mouth disease virus rescued from full-length cdna clone of serotype o, typical vaccine strain |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313104/ https://www.ncbi.nlm.nih.gov/pubmed/25648340 http://dx.doi.org/10.7774/cevr.2015.4.1.114 |
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