Microevolution of Burkholderia pseudomallei during an Acute Infection

We used whole-genome sequencing to evaluate 69 independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. Fourteen closely related genotypes were found, providing evidence for the rapid in vivo diversification of B. pseudomallei...

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Autores principales: Limmathurotsakul, Direk, Holden, Matthew T. G., Coupland, Paul, Price, Erin P., Chantratita, Narisara, Wuthiekanun, Vanaporn, Amornchai, Premjit, Parkhill, Julian, Peacock, Sharon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Bacteriology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313173/
https://www.ncbi.nlm.nih.gov/pubmed/24966357
http://dx.doi.org/10.1128/JCM.01219-14
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author Limmathurotsakul, Direk
Holden, Matthew T. G.
Coupland, Paul
Price, Erin P.
Chantratita, Narisara
Wuthiekanun, Vanaporn
Amornchai, Premjit
Parkhill, Julian
Peacock, Sharon J.
author_facet Limmathurotsakul, Direk
Holden, Matthew T. G.
Coupland, Paul
Price, Erin P.
Chantratita, Narisara
Wuthiekanun, Vanaporn
Amornchai, Premjit
Parkhill, Julian
Peacock, Sharon J.
author_sort Limmathurotsakul, Direk
collection PubMed
description We used whole-genome sequencing to evaluate 69 independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. Fourteen closely related genotypes were found, providing evidence for the rapid in vivo diversification of B. pseudomallei after inoculation and systemic spread.
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spelling pubmed-43131732015-02-02 Microevolution of Burkholderia pseudomallei during an Acute Infection Limmathurotsakul, Direk Holden, Matthew T. G. Coupland, Paul Price, Erin P. Chantratita, Narisara Wuthiekanun, Vanaporn Amornchai, Premjit Parkhill, Julian Peacock, Sharon J. J Clin Microbiol Bacteriology We used whole-genome sequencing to evaluate 69 independent colonies of Burkholderia pseudomallei isolated from seven body sites of a patient with acute disseminated melioidosis. Fourteen closely related genotypes were found, providing evidence for the rapid in vivo diversification of B. pseudomallei after inoculation and systemic spread. American Society for Microbiology 2014-09 /pmc/articles/PMC4313173/ /pubmed/24966357 http://dx.doi.org/10.1128/JCM.01219-14 Text en Copyright © 2014 Limmathurotsakul et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Bacteriology
Limmathurotsakul, Direk
Holden, Matthew T. G.
Coupland, Paul
Price, Erin P.
Chantratita, Narisara
Wuthiekanun, Vanaporn
Amornchai, Premjit
Parkhill, Julian
Peacock, Sharon J.
Microevolution of Burkholderia pseudomallei during an Acute Infection
title Microevolution of Burkholderia pseudomallei during an Acute Infection
title_full Microevolution of Burkholderia pseudomallei during an Acute Infection
title_fullStr Microevolution of Burkholderia pseudomallei during an Acute Infection
title_full_unstemmed Microevolution of Burkholderia pseudomallei during an Acute Infection
title_short Microevolution of Burkholderia pseudomallei during an Acute Infection
title_sort microevolution of burkholderia pseudomallei during an acute infection
topic Bacteriology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313173/
https://www.ncbi.nlm.nih.gov/pubmed/24966357
http://dx.doi.org/10.1128/JCM.01219-14
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