Prevalence of microcytosis in neonates: a cross-sectional study in Tehran

Background: Identification of α thalassemia (α thal) a common cause of microcytosis during neonatal periods is an important step prevent unnecessary interventions. Thus, low the mean corpuscular volume (MCV) and the mean corpuscular hemoglobin (MCH) may consider as α-thalassemia key detection points...

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Detalles Bibliográficos
Autores principales: Khalesi, Nasrin, Khosravi, Nastaran, Rezaee, Mohammad Reza, Amini, Leila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iran University of Medical Sciences 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313453/
https://www.ncbi.nlm.nih.gov/pubmed/25679000
Descripción
Sumario:Background: Identification of α thalassemia (α thal) a common cause of microcytosis during neonatal periods is an important step prevent unnecessary interventions. Thus, low the mean corpuscular volume (MCV) and the mean corpuscular hemoglobin (MCH) may consider as α-thalassemia key detection points. The present study aimed to determine the prevalence of microcytosis among neonates who born in Tehran, Iran. Methods: Cord blood samples were collected from 1001 newborns after birth in labor room and their red blood cell parameters were investigated. Results: MCV was 114.2 fl (95% CI: 113.5-114.9) and twenty three neonates (2.3%) had MCV less than 94 fL that classified as microcytosis and 4 (0.40%) had both low MCH and MCV. Conclusion: Low MCV especially in normal Hb newborns may hints for α thal detection.

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