Prevalence of microcytosis in neonates: a cross-sectional study in Tehran

Background: Identification of α thalassemia (α thal) a common cause of microcytosis during neonatal periods is an important step prevent unnecessary interventions. Thus, low the mean corpuscular volume (MCV) and the mean corpuscular hemoglobin (MCH) may consider as α-thalassemia key detection points...

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Autores principales: Khalesi, Nasrin, Khosravi, Nastaran, Rezaee, Mohammad Reza, Amini, Leila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iran University of Medical Sciences 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313453/
https://www.ncbi.nlm.nih.gov/pubmed/25679000
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author Khalesi, Nasrin
Khosravi, Nastaran
Rezaee, Mohammad Reza
Amini, Leila
author_facet Khalesi, Nasrin
Khosravi, Nastaran
Rezaee, Mohammad Reza
Amini, Leila
author_sort Khalesi, Nasrin
collection PubMed
description Background: Identification of α thalassemia (α thal) a common cause of microcytosis during neonatal periods is an important step prevent unnecessary interventions. Thus, low the mean corpuscular volume (MCV) and the mean corpuscular hemoglobin (MCH) may consider as α-thalassemia key detection points. The present study aimed to determine the prevalence of microcytosis among neonates who born in Tehran, Iran. Methods: Cord blood samples were collected from 1001 newborns after birth in labor room and their red blood cell parameters were investigated. Results: MCV was 114.2 fl (95% CI: 113.5-114.9) and twenty three neonates (2.3%) had MCV less than 94 fL that classified as microcytosis and 4 (0.40%) had both low MCH and MCV. Conclusion: Low MCV especially in normal Hb newborns may hints for α thal detection.
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spelling pubmed-43134532015-02-12 Prevalence of microcytosis in neonates: a cross-sectional study in Tehran Khalesi, Nasrin Khosravi, Nastaran Rezaee, Mohammad Reza Amini, Leila Med J Islam Repub Iran Original Article Background: Identification of α thalassemia (α thal) a common cause of microcytosis during neonatal periods is an important step prevent unnecessary interventions. Thus, low the mean corpuscular volume (MCV) and the mean corpuscular hemoglobin (MCH) may consider as α-thalassemia key detection points. The present study aimed to determine the prevalence of microcytosis among neonates who born in Tehran, Iran. Methods: Cord blood samples were collected from 1001 newborns after birth in labor room and their red blood cell parameters were investigated. Results: MCV was 114.2 fl (95% CI: 113.5-114.9) and twenty three neonates (2.3%) had MCV less than 94 fL that classified as microcytosis and 4 (0.40%) had both low MCH and MCV. Conclusion: Low MCV especially in normal Hb newborns may hints for α thal detection. Iran University of Medical Sciences 2014-10-27 /pmc/articles/PMC4313453/ /pubmed/25679000 Text en © 2014 Iran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Khalesi, Nasrin
Khosravi, Nastaran
Rezaee, Mohammad Reza
Amini, Leila
Prevalence of microcytosis in neonates: a cross-sectional study in Tehran
title Prevalence of microcytosis in neonates: a cross-sectional study in Tehran
title_full Prevalence of microcytosis in neonates: a cross-sectional study in Tehran
title_fullStr Prevalence of microcytosis in neonates: a cross-sectional study in Tehran
title_full_unstemmed Prevalence of microcytosis in neonates: a cross-sectional study in Tehran
title_short Prevalence of microcytosis in neonates: a cross-sectional study in Tehran
title_sort prevalence of microcytosis in neonates: a cross-sectional study in tehran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313453/
https://www.ncbi.nlm.nih.gov/pubmed/25679000
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AT rezaeemohammadreza prevalenceofmicrocytosisinneonatesacrosssectionalstudyintehran
AT aminileila prevalenceofmicrocytosisinneonatesacrosssectionalstudyintehran

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