NR2F1 controls tumor cell dormancy via SOX9 and RARβ driven quiescence programs

Metastases can originate from disseminated tumor cells (DTCs), which may be dormant for years before reactivation. Here we find that the orphan nuclear receptor NR2F1 is epigenetically upregulated in experimental HNSCC dormancy models and in DTCs from prostate cancer patients carrying dormant diseas...

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Detalles Bibliográficos
Autores principales: Sosa, Maria Soledad, Parikh, Falguni, Maia, Alexandre Gaspar, Estrada, Yeriel, Bosch, Almudena, Bragado, Paloma, Ekpin, Esther, George, Ajish, Zheng, Yang, Lam, Hung-Ming, Morrissey, Colm, Chung, Chi-Yeh, Farias, Eduardo F., Bernstein, Emily, Aguirre-Ghiso, Julio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313575/
https://www.ncbi.nlm.nih.gov/pubmed/25636082
http://dx.doi.org/10.1038/ncomms7170

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313575/
https://www.ncbi.nlm.nih.gov/pubmed/25636082
http://dx.doi.org/10.1038/ncomms7170

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