Kinin B1 receptor antagonism is equally efficient as angiotensin receptor 1 antagonism in reducing renal fibrosis in experimental obstructive nephropathy, but is not additive

Background: Renal tubulointerstitial fibrosis is the pathological hallmark of chronic kidney disease (CKD). Currently, inhibitors of the renin–angiotensin system (RAS) remain the sole therapy in human displaying antifibrotic properties. Further antifibrotic molecules are needed. We have recently rep...

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Detalles Bibliográficos
Autores principales: Huart, Antoine, Klein, Julie, Gonzalez, Julien, Buffin-Meyer, Bénédicte, Neau, Eric, Delage, Christine, Calise, Denis, Ribes, David, Schanstra, Joost P., Bascands, Jean-Loup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313587/
https://www.ncbi.nlm.nih.gov/pubmed/25698969
http://dx.doi.org/10.3389/fphar.2015.00008

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