Vesicular Stomatitis Virus–Based Vaccines against Lassa and Ebola Viruses

We demonstrated that previous vaccination with a vesicular stomatitis virus (VSV)–based Lassa virus vaccine does not alter protective efficacy of subsequent vaccination with a VSV-based Ebola virus vaccine. These findings demonstrate the utility of VSV-based vaccines against divergent viral pathogen...

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Autores principales: Marzi, Andrea, Feldmann, Friederike, Geisbert, Thomas W., Feldmann, Heinz, Safronetz, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2015
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313664/
https://www.ncbi.nlm.nih.gov/pubmed/25625358
http://dx.doi.org/10.3201/eid2102.141649
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author Marzi, Andrea
Feldmann, Friederike
Geisbert, Thomas W.
Feldmann, Heinz
Safronetz, David
author_facet Marzi, Andrea
Feldmann, Friederike
Geisbert, Thomas W.
Feldmann, Heinz
Safronetz, David
author_sort Marzi, Andrea
collection PubMed
description We demonstrated that previous vaccination with a vesicular stomatitis virus (VSV)–based Lassa virus vaccine does not alter protective efficacy of subsequent vaccination with a VSV-based Ebola virus vaccine. These findings demonstrate the utility of VSV-based vaccines against divergent viral pathogens, even when preexisting immunity to the vaccine vector is present.
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spelling pubmed-43136642015-02-04 Vesicular Stomatitis Virus–Based Vaccines against Lassa and Ebola Viruses Marzi, Andrea Feldmann, Friederike Geisbert, Thomas W. Feldmann, Heinz Safronetz, David Emerg Infect Dis Dispatch We demonstrated that previous vaccination with a vesicular stomatitis virus (VSV)–based Lassa virus vaccine does not alter protective efficacy of subsequent vaccination with a VSV-based Ebola virus vaccine. These findings demonstrate the utility of VSV-based vaccines against divergent viral pathogens, even when preexisting immunity to the vaccine vector is present. Centers for Disease Control and Prevention 2015-02 /pmc/articles/PMC4313664/ /pubmed/25625358 http://dx.doi.org/10.3201/eid2102.141649 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Marzi, Andrea
Feldmann, Friederike
Geisbert, Thomas W.
Feldmann, Heinz
Safronetz, David
Vesicular Stomatitis Virus–Based Vaccines against Lassa and Ebola Viruses
title Vesicular Stomatitis Virus–Based Vaccines against Lassa and Ebola Viruses
title_full Vesicular Stomatitis Virus–Based Vaccines against Lassa and Ebola Viruses
title_fullStr Vesicular Stomatitis Virus–Based Vaccines against Lassa and Ebola Viruses
title_full_unstemmed Vesicular Stomatitis Virus–Based Vaccines against Lassa and Ebola Viruses
title_short Vesicular Stomatitis Virus–Based Vaccines against Lassa and Ebola Viruses
title_sort vesicular stomatitis virus–based vaccines against lassa and ebola viruses
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313664/
https://www.ncbi.nlm.nih.gov/pubmed/25625358
http://dx.doi.org/10.3201/eid2102.141649
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