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Microbiota disbiosis is associated with colorectal cancer
The dysbiosis of the human intestinal microbiota is linked to sporadic colorectal carcinoma (CRC). The present study was designed to investigate the gut microbiota distribution features in CRC patients. We performed pyrosequencing based analysis of the 16S rRNA gene V3 region to investigate microbio...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313696/ https://www.ncbi.nlm.nih.gov/pubmed/25699023 http://dx.doi.org/10.3389/fmicb.2015.00020 |
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author | Gao, Zhiguang Guo, Bomin Gao, Renyuan Zhu, Qingchao Qin, Huanlong |
author_facet | Gao, Zhiguang Guo, Bomin Gao, Renyuan Zhu, Qingchao Qin, Huanlong |
author_sort | Gao, Zhiguang |
collection | PubMed |
description | The dysbiosis of the human intestinal microbiota is linked to sporadic colorectal carcinoma (CRC). The present study was designed to investigate the gut microbiota distribution features in CRC patients. We performed pyrosequencing based analysis of the 16S rRNA gene V3 region to investigate microbiota of the cancerous tissue and adjacent non-cancerous normal tissue in proximal and distal CRC samples. The results revealed that the microbial structures of the CRC patients and healthy individuals differed significantly. Firmicutes and Fusobacteria were over-represented whereas Proteobacteria was under-represented in CRC patients. In addition, Lactococcus and Fusobacterium exhibited a relatively higher abundance while Pseudomonas and Escherichia-Shigella was reduced in cancerous tissues compared to adjacent non-cancerous tissues. Meanwhile, the overall microbial structures of proximal and distal colon cancerous tissues were similar; but certain potential pro-oncogenic pathogens were different. These results suggested that the mucosa-associated microbiota is dynamically associated with CRC, which may provide evidences for microbiota-associated diagnostic, prognostic, preventive, and therapeutic strategies for CRC. |
format | Online Article Text |
id | pubmed-4313696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-43136962015-02-19 Microbiota disbiosis is associated with colorectal cancer Gao, Zhiguang Guo, Bomin Gao, Renyuan Zhu, Qingchao Qin, Huanlong Front Microbiol Public Health The dysbiosis of the human intestinal microbiota is linked to sporadic colorectal carcinoma (CRC). The present study was designed to investigate the gut microbiota distribution features in CRC patients. We performed pyrosequencing based analysis of the 16S rRNA gene V3 region to investigate microbiota of the cancerous tissue and adjacent non-cancerous normal tissue in proximal and distal CRC samples. The results revealed that the microbial structures of the CRC patients and healthy individuals differed significantly. Firmicutes and Fusobacteria were over-represented whereas Proteobacteria was under-represented in CRC patients. In addition, Lactococcus and Fusobacterium exhibited a relatively higher abundance while Pseudomonas and Escherichia-Shigella was reduced in cancerous tissues compared to adjacent non-cancerous tissues. Meanwhile, the overall microbial structures of proximal and distal colon cancerous tissues were similar; but certain potential pro-oncogenic pathogens were different. These results suggested that the mucosa-associated microbiota is dynamically associated with CRC, which may provide evidences for microbiota-associated diagnostic, prognostic, preventive, and therapeutic strategies for CRC. Frontiers Media S.A. 2015-02-02 /pmc/articles/PMC4313696/ /pubmed/25699023 http://dx.doi.org/10.3389/fmicb.2015.00020 Text en Copyright © 2015 Gao, Guo, Gao, Zhu and Qin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Gao, Zhiguang Guo, Bomin Gao, Renyuan Zhu, Qingchao Qin, Huanlong Microbiota disbiosis is associated with colorectal cancer |
title | Microbiota disbiosis is associated with colorectal cancer |
title_full | Microbiota disbiosis is associated with colorectal cancer |
title_fullStr | Microbiota disbiosis is associated with colorectal cancer |
title_full_unstemmed | Microbiota disbiosis is associated with colorectal cancer |
title_short | Microbiota disbiosis is associated with colorectal cancer |
title_sort | microbiota disbiosis is associated with colorectal cancer |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313696/ https://www.ncbi.nlm.nih.gov/pubmed/25699023 http://dx.doi.org/10.3389/fmicb.2015.00020 |
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