Potential Applications of Image-Guided Radiotherapy for Radiation Dose Escalation in Patients with Early Stage High-Risk Prostate Cancer

Patients with early stage high-risk prostate cancer (prostate specific antigen > 20, Gleason score > 7) are at high risk of recurrence following prostate cancer irradiation. Radiation dose escalation to the prostate may improve biochemical-free survival for these patients. However, high rectal...

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Autores principales: Nguyen, Nam P., Davis, Rick, Bose, Satya R., Dutta, Suresh, Vinh-Hung, Vincent, Chi, Alexander, Godinez, Juan, Desai, Anand, Woods, William, Altdorfer, Gabor, D’Andrea, Mark, Karlsson, Ulf, Vo, Richard A., Sroka, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313771/
https://www.ncbi.nlm.nih.gov/pubmed/25699239
http://dx.doi.org/10.3389/fonc.2015.00018
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author Nguyen, Nam P.
Davis, Rick
Bose, Satya R.
Dutta, Suresh
Vinh-Hung, Vincent
Chi, Alexander
Godinez, Juan
Desai, Anand
Woods, William
Altdorfer, Gabor
D’Andrea, Mark
Karlsson, Ulf
Vo, Richard A.
Sroka, Thomas
author_facet Nguyen, Nam P.
Davis, Rick
Bose, Satya R.
Dutta, Suresh
Vinh-Hung, Vincent
Chi, Alexander
Godinez, Juan
Desai, Anand
Woods, William
Altdorfer, Gabor
D’Andrea, Mark
Karlsson, Ulf
Vo, Richard A.
Sroka, Thomas
author_sort Nguyen, Nam P.
collection PubMed
description Patients with early stage high-risk prostate cancer (prostate specific antigen > 20, Gleason score > 7) are at high risk of recurrence following prostate cancer irradiation. Radiation dose escalation to the prostate may improve biochemical-free survival for these patients. However, high rectal and bladder dose with conventional three-dimensional conformal radiotherapy may lead to excessive gastrointestinal and genitourinary toxicity. Image-guided radiotherapy (IGRT), by virtue of combining the steep dose gradient of intensity-modulated radiotherapy and daily pretreatment imaging, may allow for radiation dose escalation and decreased treatment morbidity. Reduced treatment time is feasible with hypo-fractionated IGRT and it may improve patient quality of life.
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spelling pubmed-43137712015-02-19 Potential Applications of Image-Guided Radiotherapy for Radiation Dose Escalation in Patients with Early Stage High-Risk Prostate Cancer Nguyen, Nam P. Davis, Rick Bose, Satya R. Dutta, Suresh Vinh-Hung, Vincent Chi, Alexander Godinez, Juan Desai, Anand Woods, William Altdorfer, Gabor D’Andrea, Mark Karlsson, Ulf Vo, Richard A. Sroka, Thomas Front Oncol Oncology Patients with early stage high-risk prostate cancer (prostate specific antigen > 20, Gleason score > 7) are at high risk of recurrence following prostate cancer irradiation. Radiation dose escalation to the prostate may improve biochemical-free survival for these patients. However, high rectal and bladder dose with conventional three-dimensional conformal radiotherapy may lead to excessive gastrointestinal and genitourinary toxicity. Image-guided radiotherapy (IGRT), by virtue of combining the steep dose gradient of intensity-modulated radiotherapy and daily pretreatment imaging, may allow for radiation dose escalation and decreased treatment morbidity. Reduced treatment time is feasible with hypo-fractionated IGRT and it may improve patient quality of life. Frontiers Media S.A. 2015-02-02 /pmc/articles/PMC4313771/ /pubmed/25699239 http://dx.doi.org/10.3389/fonc.2015.00018 Text en Copyright © 2015 Nguyen, Davis, Bose, Dutta, Vinh-Hung, Chi, Godinez, Desai, Woods, Altdorfer, D’Andrea, Karlsson, Vo, Sroka and the International Geriatric Radiotherapy Group. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Nguyen, Nam P.
Davis, Rick
Bose, Satya R.
Dutta, Suresh
Vinh-Hung, Vincent
Chi, Alexander
Godinez, Juan
Desai, Anand
Woods, William
Altdorfer, Gabor
D’Andrea, Mark
Karlsson, Ulf
Vo, Richard A.
Sroka, Thomas
Potential Applications of Image-Guided Radiotherapy for Radiation Dose Escalation in Patients with Early Stage High-Risk Prostate Cancer
title Potential Applications of Image-Guided Radiotherapy for Radiation Dose Escalation in Patients with Early Stage High-Risk Prostate Cancer
title_full Potential Applications of Image-Guided Radiotherapy for Radiation Dose Escalation in Patients with Early Stage High-Risk Prostate Cancer
title_fullStr Potential Applications of Image-Guided Radiotherapy for Radiation Dose Escalation in Patients with Early Stage High-Risk Prostate Cancer
title_full_unstemmed Potential Applications of Image-Guided Radiotherapy for Radiation Dose Escalation in Patients with Early Stage High-Risk Prostate Cancer
title_short Potential Applications of Image-Guided Radiotherapy for Radiation Dose Escalation in Patients with Early Stage High-Risk Prostate Cancer
title_sort potential applications of image-guided radiotherapy for radiation dose escalation in patients with early stage high-risk prostate cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313771/
https://www.ncbi.nlm.nih.gov/pubmed/25699239
http://dx.doi.org/10.3389/fonc.2015.00018
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