Cargando…

Insulin/Insulin-Like Growth Factors in Cancer: New Roles for the Aryl Hydrocarbon Receptor, Tumor Resistance Mechanisms, and New Blocking Strategies

The insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor (IR) are receptor tyrosine kinases that are expressed in cancer cells. The results of different studies indicate that tumor proliferation and survival is dependent on the IGF1R and IR, and that their inhibition leads to reduc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Salisbury, Travis B., Tomblin, Justin K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313785/ https://www.ncbi.nlm.nih.gov/pubmed/25699021 http://dx.doi.org/10.3389/fendo.2015.00012

Ejemplares similares

Aryl Hydrocarbon Receptor Ligands Inhibit IGF-II and Adipokine Stimulated Breast Cancer Cell Proliferation
por: Salisbury, Travis B., et al.
Publicado: (2013)

Insulin-like growth factor-II: new roles for an old actor
por: Cianfarani, Stefano
Publicado: (2012)

Ligand-Mediated Endocytosis and Trafficking of the Insulin-Like Growth Factor Receptor I and Insulin Receptor Modulate Receptor Function
por: Morcavallo, Alaide, et al.
Publicado: (2014)

All-Atom Structural Models of the Transmembrane Domains of Insulin and Type 1 Insulin-Like Growth Factor Receptors
por: Mohammadiarani, Hossein, et al.
Publicado: (2016)

Somatic Deletion in Exon 10 of Aryl Hydrocarbon Receptor Gene in Human GH-Secreting Pituitary Tumors
por: Re, Agnese, et al.
Publicado: (2020)

The Insulin Receptor: A New Target for Cancer Therapy
por: Malaguarnera, Roberta, et al.
Publicado: (2011)

Insulin-Like Growth Factor Pathway and the Thyroid
por: Smith, Terry J.
Publicado: (2021)

The Emerging Role of Insulin and Insulin-Like Growth Factor Signaling in Cancer Stem Cells
por: Malaguarnera, Roberta, et al.
Publicado: (2014)

New Trends in Aryl Hydrocarbon Receptor Biology
por: Mulero-Navarro, Sonia, et al.
Publicado: (2016)

Crosstalk of the Insulin-Like Growth Factor Receptor with the Wnt Signaling Pathway in Breast Cancer
por: Rota, Lauren M., et al.
Publicado: (2015)

Controlled Signaling—Insulin-Like Growth Factor Receptor Endocytosis and Presence at Intracellular Compartments
por: Rieger, Leonie, et al.
Publicado: (2021)

Growth Hormone and Insulin-Like Growth Factor Action in Reproductive Tissues
por: Ipsa, Emina, et al.
Publicado: (2019)

Estradiol Binds to Insulin and Insulin Receptor Decreasing Insulin Binding in vitro
por: Root-Bernstein, Robert, et al.
Publicado: (2014)

Aging Regulated Through a Stability Model of Insulin/Insulin Growth Factor Receptor Function
por: Tatar, Marc
Publicado: (2021)

Building the Case for Insulin-Like Growth Factor Receptor-I Involvement in Thyroid-Associated Ophthalmopathy
por: Smith, Terry J., et al.
Publicado: (2017)

Insulin-Like Growth Factor Binding Proteins in Autoimmune Diseases
por: Ding, Huihua, et al.
Publicado: (2018)

Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes
por: Garcia de la Serrana, Daniel, et al.
Publicado: (2018)

The aryl hydrocarbon receptor in tumor immunity
por: Platten, Michael, et al.
Publicado: (2012)

The Aryl Hydrocarbon Receptor and Tumor Immunity
por: Xue, Ping, et al.
Publicado: (2018)

Association between polymorphisms in the aryl hydrocarbon receptor repressor gene and disseminated testicular germ cell cancer
por: Brokken, Leon J. S., et al.
Publicado: (2013)

Differential Effects of Camel Milk on Insulin Receptor Signaling – Toward Understanding the Insulin-Like Properties of Camel Milk
por: Abdulrahman, Abdulrasheed O., et al.
Publicado: (2016)

Insulin-Like Growth Factor Binding Proteins: A Structural Perspective
por: Forbes, Briony E., et al.
Publicado: (2012)

Insulin-Like Growth Factor Binding Protein-5 in Physiology and Disease
por: Duan, Cunming, et al.
Publicado: (2020)

Insulin-like growth factors and aging: lessons from Laron syndrome
por: Werner, Haim, et al.
Publicado: (2023)

Effects of Transport Duration and Environmental Conditions in Winter or Summer on the Concentrations of Insulin-Like Growth Factors and Insulin-Like Growth Factor-Binding Proteins in the Plasma of Market-Weight Pigs
por: Wirthgen, Elisa, et al.
Publicado: (2018)

Structural Perspectives of Insulin Receptor Isoform-Selective Insulin Analogs
por: Jiráček, Jiří, et al.
Publicado: (2017)

Insulin-like growth factor-1 signaling in the tumor microenvironment: Carcinogenesis, cancer drug resistance, and therapeutic potential
por: Nwabo Kamdje, Armel H., et al.
Publicado: (2022)

The clinical and therapeutic profiles of prolactinomas associated with germline pathogenic variants in the aryl hydrocarbon receptor interacting protein (AIP) gene
por: Vroonen, Laurent, et al.
Publicado: (2023)

Corrigendum: Insulin-Like Growth Factor Binding Protein-5 in Physiology and Disease
por: Duan, Cunming, et al.
Publicado: (2020)

Insulin-like growth factor-1 levels are associated with interventricular septal thickening
por: Chen, Yuan, et al.
Publicado: (2022)

Aryl Hydrocarbon Receptor Deficiency Enhances Insulin Sensitivity and Reduces PPAR-α Pathway Activity in Mice
por: Wang, Chun, et al.
Publicado: (2011)

Upregulation of Aryl Hydrocarbon Receptor in Granulosa Cells by Endoplasmic Reticulum Stress Contributes to the PCOS Pathophysiology
por: Kunitomi, Chisato, et al.
Publicado: (2021)

The Role of the Insulin-Like Growth Factor 1 Pathway in Immune Tumor Microenvironment and Its Clinical Ramifications in Gynecologic Malignancies
por: Yahya, Muna Alemi, et al.
Publicado: (2018)

Cross-Linking/Mass Spectrometry Uncovers Details of Insulin-Like Growth Factor Interaction With Insect Insulin Binding Protein Imp-L2
por: Pompach, Petr, et al.
Publicado: (2019)

Growth Hormone(s), Testosterone, Insulin-Like Growth Factors, and Cortisol: Roles and Integration for Cellular Development and Growth With Exercise
por: Kraemer, William J., et al.
Publicado: (2020)

Editorial: Current Perspectives on Insulin-Like Growth Factor Binding Protein (IGFBP) Research
por: Hoeflich, Andreas, et al.
Publicado: (2018)

Identification of BRCA1 As a Potential Biomarker for Insulin-Like Growth Factor-1 Receptor Targeted Therapy in Breast Cancer
por: Cohen-Sinai, Tali, et al.
Publicado: (2017)

Coffee Is Associated With Lower Breast Tumor Insulin-Like Growth Factor Receptor 1 Levels in Normal-Weight Patients and Improved Prognosis Following Tamoxifen or Radiotherapy Treatment
por: Björner, Sofie, et al.
Publicado: (2018)

A Protective Role of Aryl Hydrocarbon Receptor Repressor in Inflammation and Tumor Growth
por: Vogel, Christoph F. A., et al.
Publicado: (2019)

Insight into the physiological and pathological roles of the aryl hydrocarbon receptor pathway in glucose homeostasis, insulin resistance, and diabetes development
por: Sayed, Tahseen S., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9cauatrgjg9r4unmdm9gsml6ed