Age-related cancer mutations associated with clonal hematopoietic expansion

Several genetic alterations characteristic of leukemia and lymphoma have been detected in the blood of individuals without apparent hematological malignancies. We analyzed blood-derived sequence data from 2,728 individuals within The Cancer Genome Atlas, and discovered 77 blood-specific mutations in...

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Detalles Bibliográficos
Autores principales: Xie, Mingchao, Lu, Charles, Wang, Jiayin, McLellan, Michael D., Johnson, Kimberly J., Wendl, Michael C., McMichael, Joshua F., Schmidt, Heather K., Yellapantula, Venkata, Miller, Christopher A., Ozenberger, Bradley A., Welch, John S., Link, Daniel C., Walter, Matthew J., Mardis, Elaine R., Dipersio, John F., Chen, Feng, Wilson, Richard K., Ley, Timothy J., Ding, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313872/
https://www.ncbi.nlm.nih.gov/pubmed/25326804
http://dx.doi.org/10.1038/nm.3733

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