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Plasma Soluble Prion Protein, a Potential Biomarker for Sport-Related Concussions: A Pilot Study

Sport-related mild traumatic brain injury (mTBI) or concussion is a significant health concern to athletes with potential long-term consequences. The diagnosis of sport concussion and return to sport decision making is one of the greatest challenges facing health care clinicians working in sports. B...

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Detalles Bibliográficos
Autores principales: Pham, Nam, Akonasu, Hungbo, Shishkin, Rhonda, Taghibiglou, Changiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314282/
https://www.ncbi.nlm.nih.gov/pubmed/25643046
http://dx.doi.org/10.1371/journal.pone.0117286
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author Pham, Nam
Akonasu, Hungbo
Shishkin, Rhonda
Taghibiglou, Changiz
author_facet Pham, Nam
Akonasu, Hungbo
Shishkin, Rhonda
Taghibiglou, Changiz
author_sort Pham, Nam
collection PubMed
description Sport-related mild traumatic brain injury (mTBI) or concussion is a significant health concern to athletes with potential long-term consequences. The diagnosis of sport concussion and return to sport decision making is one of the greatest challenges facing health care clinicians working in sports. Blood biomarkers have recently demonstrated their potential in assisting the detection of brain injury particularly, in those cases with no obvious physical injury. We have recently discovered plasma soluble cellular prion protein (PrP(C)) as a potential reliable biomarker for blast induced TBI (bTBI) in a rodent animal model. In order to explore the application of this novel TBI biomarker to sport-related concussion, we conducted a pilot study at the University of Saskatchewan (U of S) by recruiting athlete and non-athlete 18 to 30 year-old students. Using a modified quantitative ELISA method, we first established normal values for the plasma soluble PrP(C) in male and female students. The measured plasma soluble PrP(C) in confirmed concussion cases demonstrated a significant elevation of this analyte in post-concussion samples. Data collected from our pilot study indicates that the plasma soluble PrP(C) is a potential biomarker for sport-related concussion, which may be further developed into a clinical diagnostic tool to assist clinicians in the assessment of sport concussion and return-to-play decision making.
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spelling pubmed-43142822015-02-13 Plasma Soluble Prion Protein, a Potential Biomarker for Sport-Related Concussions: A Pilot Study Pham, Nam Akonasu, Hungbo Shishkin, Rhonda Taghibiglou, Changiz PLoS One Research Article Sport-related mild traumatic brain injury (mTBI) or concussion is a significant health concern to athletes with potential long-term consequences. The diagnosis of sport concussion and return to sport decision making is one of the greatest challenges facing health care clinicians working in sports. Blood biomarkers have recently demonstrated their potential in assisting the detection of brain injury particularly, in those cases with no obvious physical injury. We have recently discovered plasma soluble cellular prion protein (PrP(C)) as a potential reliable biomarker for blast induced TBI (bTBI) in a rodent animal model. In order to explore the application of this novel TBI biomarker to sport-related concussion, we conducted a pilot study at the University of Saskatchewan (U of S) by recruiting athlete and non-athlete 18 to 30 year-old students. Using a modified quantitative ELISA method, we first established normal values for the plasma soluble PrP(C) in male and female students. The measured plasma soluble PrP(C) in confirmed concussion cases demonstrated a significant elevation of this analyte in post-concussion samples. Data collected from our pilot study indicates that the plasma soluble PrP(C) is a potential biomarker for sport-related concussion, which may be further developed into a clinical diagnostic tool to assist clinicians in the assessment of sport concussion and return-to-play decision making. Public Library of Science 2015-02-02 /pmc/articles/PMC4314282/ /pubmed/25643046 http://dx.doi.org/10.1371/journal.pone.0117286 Text en © 2015 Pham et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Pham, Nam
Akonasu, Hungbo
Shishkin, Rhonda
Taghibiglou, Changiz
Plasma Soluble Prion Protein, a Potential Biomarker for Sport-Related Concussions: A Pilot Study
title Plasma Soluble Prion Protein, a Potential Biomarker for Sport-Related Concussions: A Pilot Study
title_full Plasma Soluble Prion Protein, a Potential Biomarker for Sport-Related Concussions: A Pilot Study
title_fullStr Plasma Soluble Prion Protein, a Potential Biomarker for Sport-Related Concussions: A Pilot Study
title_full_unstemmed Plasma Soluble Prion Protein, a Potential Biomarker for Sport-Related Concussions: A Pilot Study
title_short Plasma Soluble Prion Protein, a Potential Biomarker for Sport-Related Concussions: A Pilot Study
title_sort plasma soluble prion protein, a potential biomarker for sport-related concussions: a pilot study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314282/
https://www.ncbi.nlm.nih.gov/pubmed/25643046
http://dx.doi.org/10.1371/journal.pone.0117286
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