Tumor-targeting novel manganese complex induces ROS-mediated apoptotic and autophagic cancer cell death

In this study, the antitumor activity of the novel manganese (II) compound, Adpa-Mn {[(Adpa)Mn(Cl)(H(2)O)] (Adpa=bis(2-pyridylmethyl)amino-2-propionic acid)}, and its possible mechanisms of action were investigated. In vitro, the growth inhibitory effects of Adpa-Mn (with IC(50) values lower than 15...

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Detalles Bibliográficos
Autores principales: LIU, JIA, GUO, WENJIE, LI, JING, LI, XIANG, GENG, JI, CHEN, QIUYUN, GAO, JING
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314420/
https://www.ncbi.nlm.nih.gov/pubmed/25604962
http://dx.doi.org/10.3892/ijmm.2015.2073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314420/
https://www.ncbi.nlm.nih.gov/pubmed/25604962
http://dx.doi.org/10.3892/ijmm.2015.2073

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