Autophagy collaborates with ubiquitination to downregulate oncoprotein E2A/Pbx1 in B-cell acute lymphoblastic leukemia

B-cell acute lymphoblastic leukemia (B-ALL) accounts for the most cancer incidences in children. We present here that autophagy is downregulated in pediatric B-ALL, suggesting a possible link between autophagy failure and pediatric B-ALL leukemogenesis. With a pediatric t(1;19) B-ALL xenograft mouse...

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Detalles Bibliográficos
Autores principales: Yuan, N, Song, L, Lin, W, Cao, Y, Xu, F, Liu, S, Zhang, A, Wang, Z, Li, X, Fang, Y, Zhang, H, Zhao, W, Hu, S, Wang, J, Zhang, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314458/
https://www.ncbi.nlm.nih.gov/pubmed/25615280
http://dx.doi.org/10.1038/bcj.2014.96

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