Angiotensin-converting enzyme 2/angiotensin-(1–7)/Mas axis prevents lipopolysaccharide–induced apoptosis of pulmonary microvascular endothelial cells by inhibiting JNK/NF–κB pathways

ACE2 and Ang–(1–7) have important roles in preventing acute lung injury. However, it is not clear whether upregulation of the ACE2/Ang–(1–7)/Mas axis prevents LPS–induced injury in pulmonary microvascular endothelial cells (PMVECs) by inhibiting the MAPKs/NF–κB pathways. Primary cultured rat PMVECs...

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Detalles Bibliográficos
Autores principales: Li, Yingchuan, Cao, Yongmei, Zeng, Zhen, Liang, Mengfan, Xue, Ying, Xi, Caihua, Zhou, Ming, Jiang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314638/
https://www.ncbi.nlm.nih.gov/pubmed/25644821
http://dx.doi.org/10.1038/srep08209

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