Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1β

BACKGROUND: Galectin-3 (gal-3), a member of the β-galactoside-binding animal lectins, is involved in the recruitment, activation and removal of neutrophils. Neutrophilic asthma is characterized by a persistent elevation of airway neutrophils and impaired efferocytosis. We hypothesized that sputum ga...

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Detalles Bibliográficos
Autores principales: Gao, Peng, Gibson, Peter G, Baines, Katherine J, Yang, Ian A, Upham, John W, Reynolds, Paul N, Hodge, Sandra, James, Alan L, Jenkins, Christine, Peters, Matthew J, Zhang, Jie, Simpson, Jodie L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314745/
https://www.ncbi.nlm.nih.gov/pubmed/25616863
http://dx.doi.org/10.1186/s12931-014-0163-5

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