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Upregulation of the B7/CD28 family member B7-H3 in bladder cancer
Dysregulation of B7-H3 has been observed in a variety of types of human cancers. In the present study, the mRNA expression level of B7-H3 was analyzed in bladder cancer by performing semi-quantitative reverse transcription-polymerase chain reaction on clinical specimens from transitional cell carcin...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314980/ https://www.ncbi.nlm.nih.gov/pubmed/25663925 http://dx.doi.org/10.3892/ol.2014.2828 |
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author | WU, DEYAO ZHANG, ZICHUN PAN, HUIXING FAN, YUANFENG QU, PING ZHOU, JIAN |
author_facet | WU, DEYAO ZHANG, ZICHUN PAN, HUIXING FAN, YUANFENG QU, PING ZHOU, JIAN |
author_sort | WU, DEYAO |
collection | PubMed |
description | Dysregulation of B7-H3 has been observed in a variety of types of human cancers. In the present study, the mRNA expression level of B7-H3 was analyzed in bladder cancer by performing semi-quantitative reverse transcription-polymerase chain reaction on clinical specimens from transitional cell carcinomas (TCCs) and their normal adjacent tissues (NATs). Immunohistochemical analysis was performed to compare the protein expression level of B7-H3 in TCCs and the paired NATs. The present study indicated that the B7-H3 mRNA expression level was significantly higher in the TCC samples compared with the paired NAT samples. Furthermore, immunohistochemical analyses indicated that the B7-H3 protein expression level was significantly upregulated in the TCC samples compared with in the paired NAT samples, indicating that B7-H3 dysregulation may be important in the progression of bladder cancer. |
format | Online Article Text |
id | pubmed-4314980 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-43149802015-02-06 Upregulation of the B7/CD28 family member B7-H3 in bladder cancer WU, DEYAO ZHANG, ZICHUN PAN, HUIXING FAN, YUANFENG QU, PING ZHOU, JIAN Oncol Lett Articles Dysregulation of B7-H3 has been observed in a variety of types of human cancers. In the present study, the mRNA expression level of B7-H3 was analyzed in bladder cancer by performing semi-quantitative reverse transcription-polymerase chain reaction on clinical specimens from transitional cell carcinomas (TCCs) and their normal adjacent tissues (NATs). Immunohistochemical analysis was performed to compare the protein expression level of B7-H3 in TCCs and the paired NATs. The present study indicated that the B7-H3 mRNA expression level was significantly higher in the TCC samples compared with the paired NAT samples. Furthermore, immunohistochemical analyses indicated that the B7-H3 protein expression level was significantly upregulated in the TCC samples compared with in the paired NAT samples, indicating that B7-H3 dysregulation may be important in the progression of bladder cancer. D.A. Spandidos 2015-03 2014-12-23 /pmc/articles/PMC4314980/ /pubmed/25663925 http://dx.doi.org/10.3892/ol.2014.2828 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles WU, DEYAO ZHANG, ZICHUN PAN, HUIXING FAN, YUANFENG QU, PING ZHOU, JIAN Upregulation of the B7/CD28 family member B7-H3 in bladder cancer |
title | Upregulation of the B7/CD28 family member B7-H3 in bladder cancer |
title_full | Upregulation of the B7/CD28 family member B7-H3 in bladder cancer |
title_fullStr | Upregulation of the B7/CD28 family member B7-H3 in bladder cancer |
title_full_unstemmed | Upregulation of the B7/CD28 family member B7-H3 in bladder cancer |
title_short | Upregulation of the B7/CD28 family member B7-H3 in bladder cancer |
title_sort | upregulation of the b7/cd28 family member b7-h3 in bladder cancer |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314980/ https://www.ncbi.nlm.nih.gov/pubmed/25663925 http://dx.doi.org/10.3892/ol.2014.2828 |
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