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How the cell cycle impacts chromatin architecture and influences cell fate

Since the earliest observations of cells undergoing mitosis, it has been clear that there is an intimate relationship between the cell cycle and nuclear chromatin architecture. The nuclear envelope and chromatin undergo robust assembly and disassembly during the cell cycle, and transcriptional and p...

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Autores principales: Ma, Yiqin, Kanakousaki, Kiriaki, Buttitta, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315090/
https://www.ncbi.nlm.nih.gov/pubmed/25691891
http://dx.doi.org/10.3389/fgene.2015.00019
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author Ma, Yiqin
Kanakousaki, Kiriaki
Buttitta, Laura
author_facet Ma, Yiqin
Kanakousaki, Kiriaki
Buttitta, Laura
author_sort Ma, Yiqin
collection PubMed
description Since the earliest observations of cells undergoing mitosis, it has been clear that there is an intimate relationship between the cell cycle and nuclear chromatin architecture. The nuclear envelope and chromatin undergo robust assembly and disassembly during the cell cycle, and transcriptional and post-transcriptional regulation of histone biogenesis and chromatin modification is controlled in a cell cycle-dependent manner. Chromatin binding proteins and chromatin modifications in turn influence the expression of critical cell cycle regulators, the accessibility of origins for DNA replication, DNA repair, and cell fate. In this review we aim to provide an integrated discussion of how the cell cycle machinery impacts nuclear architecture and vice-versa. We highlight recent advances in understanding cell cycle-dependent histone biogenesis and histone modification deposition, how cell cycle regulators control histone modifier activities, the contribution of chromatin modifications to origin firing for DNA replication, and newly identified roles for nucleoporins in regulating cell cycle gene expression, gene expression memory and differentiation. We close with a discussion of how cell cycle status may impact chromatin to influence cell fate decisions, under normal contexts of differentiation as well as in instances of cell fate reprogramming.
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spelling pubmed-43150902015-02-17 How the cell cycle impacts chromatin architecture and influences cell fate Ma, Yiqin Kanakousaki, Kiriaki Buttitta, Laura Front Genet Genetics Since the earliest observations of cells undergoing mitosis, it has been clear that there is an intimate relationship between the cell cycle and nuclear chromatin architecture. The nuclear envelope and chromatin undergo robust assembly and disassembly during the cell cycle, and transcriptional and post-transcriptional regulation of histone biogenesis and chromatin modification is controlled in a cell cycle-dependent manner. Chromatin binding proteins and chromatin modifications in turn influence the expression of critical cell cycle regulators, the accessibility of origins for DNA replication, DNA repair, and cell fate. In this review we aim to provide an integrated discussion of how the cell cycle machinery impacts nuclear architecture and vice-versa. We highlight recent advances in understanding cell cycle-dependent histone biogenesis and histone modification deposition, how cell cycle regulators control histone modifier activities, the contribution of chromatin modifications to origin firing for DNA replication, and newly identified roles for nucleoporins in regulating cell cycle gene expression, gene expression memory and differentiation. We close with a discussion of how cell cycle status may impact chromatin to influence cell fate decisions, under normal contexts of differentiation as well as in instances of cell fate reprogramming. Frontiers Media S.A. 2015-02-03 /pmc/articles/PMC4315090/ /pubmed/25691891 http://dx.doi.org/10.3389/fgene.2015.00019 Text en Copyright © 2015 Ma, Kanakousaki and Buttitta. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Ma, Yiqin
Kanakousaki, Kiriaki
Buttitta, Laura
How the cell cycle impacts chromatin architecture and influences cell fate
title How the cell cycle impacts chromatin architecture and influences cell fate
title_full How the cell cycle impacts chromatin architecture and influences cell fate
title_fullStr How the cell cycle impacts chromatin architecture and influences cell fate
title_full_unstemmed How the cell cycle impacts chromatin architecture and influences cell fate
title_short How the cell cycle impacts chromatin architecture and influences cell fate
title_sort how the cell cycle impacts chromatin architecture and influences cell fate
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315090/
https://www.ncbi.nlm.nih.gov/pubmed/25691891
http://dx.doi.org/10.3389/fgene.2015.00019
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