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Tryptophan-Degrading Enzymes in Tumoral Immune Resistance

Tryptophan is required for T lymphocyte effector functions. Its degradation is one of the mechanisms selected by tumors to resist immune destruction. Two enzymes, tryptophan-2,3-dioxygenase and indoleamine 2,3-dioxygenase 1, control tryptophan degradation through the kynurenine pathway. A third prot...

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Detalles Bibliográficos
Autores principales:	van Baren, Nicolas, Van den Eynde, Benoît J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315104/ https://www.ncbi.nlm.nih.gov/pubmed/25691885 http://dx.doi.org/10.3389/fimmu.2015.00034

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