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A nano-disperse ferritin-core mimetic that efficiently corrects anemia without luminal iron redox activity

The 2-5 nm Fe(III) oxo-hydroxide core of ferritin is less ordered and readily bioavailable compared to its pure synthetic analogue, ferrihydrite. We report the facile synthesis of tartrate-modified, nano-disperse ferrihydrite of small primary particle size, but with enlarged or strained lattice stru...

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Autores principales: Powell, Jonathan J., Bruggraber, Sylvaine F.A., Faria, Nuno, Poots, Lynsey K., Hondow, Nicole, Pennycook, Timothy J., Latunde-Dada, Gladys O., Simpson, Robert J., Brown, Andy P., Pereira, Dora I.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315135/
https://www.ncbi.nlm.nih.gov/pubmed/24394211
http://dx.doi.org/10.1016/j.nano.2013.12.011
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author Powell, Jonathan J.
Bruggraber, Sylvaine F.A.
Faria, Nuno
Poots, Lynsey K.
Hondow, Nicole
Pennycook, Timothy J.
Latunde-Dada, Gladys O.
Simpson, Robert J.
Brown, Andy P.
Pereira, Dora I.A.
author_facet Powell, Jonathan J.
Bruggraber, Sylvaine F.A.
Faria, Nuno
Poots, Lynsey K.
Hondow, Nicole
Pennycook, Timothy J.
Latunde-Dada, Gladys O.
Simpson, Robert J.
Brown, Andy P.
Pereira, Dora I.A.
author_sort Powell, Jonathan J.
collection PubMed
description The 2-5 nm Fe(III) oxo-hydroxide core of ferritin is less ordered and readily bioavailable compared to its pure synthetic analogue, ferrihydrite. We report the facile synthesis of tartrate-modified, nano-disperse ferrihydrite of small primary particle size, but with enlarged or strained lattice structure (~ 2.7 Å for the main Bragg peak versus 2.6 Å for synthetic ferrihydrite). Analysis indicated that co-precipitation conditions can be achieved for tartrate inclusion into the developing ferrihydrite particles, retarding both growth and crystallization and favoring stabilization of the cross-linked polymeric structure. In murine models, gastrointestinal uptake was independent of luminal Fe(III) reduction to Fe(II) and, yet, absorption was equivalent to that of ferrous sulphate, efficiently correcting the induced anemia. This process may model dietary Fe(III) absorption and potentially provide a side effect-free form of cheap supplemental iron. FROM THE CLINICAL EDITOR: Small size tartrate-modified, nano-disperse ferrihydrite was used for efficient gastrointestinal delivery of soluble Fe(III) without the risk for free radical generation in murine models. This method may provide a potentially side effect-free form iron supplementation.
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spelling pubmed-43151352015-02-14 A nano-disperse ferritin-core mimetic that efficiently corrects anemia without luminal iron redox activity Powell, Jonathan J. Bruggraber, Sylvaine F.A. Faria, Nuno Poots, Lynsey K. Hondow, Nicole Pennycook, Timothy J. Latunde-Dada, Gladys O. Simpson, Robert J. Brown, Andy P. Pereira, Dora I.A. Nanomedicine Original Article The 2-5 nm Fe(III) oxo-hydroxide core of ferritin is less ordered and readily bioavailable compared to its pure synthetic analogue, ferrihydrite. We report the facile synthesis of tartrate-modified, nano-disperse ferrihydrite of small primary particle size, but with enlarged or strained lattice structure (~ 2.7 Å for the main Bragg peak versus 2.6 Å for synthetic ferrihydrite). Analysis indicated that co-precipitation conditions can be achieved for tartrate inclusion into the developing ferrihydrite particles, retarding both growth and crystallization and favoring stabilization of the cross-linked polymeric structure. In murine models, gastrointestinal uptake was independent of luminal Fe(III) reduction to Fe(II) and, yet, absorption was equivalent to that of ferrous sulphate, efficiently correcting the induced anemia. This process may model dietary Fe(III) absorption and potentially provide a side effect-free form of cheap supplemental iron. FROM THE CLINICAL EDITOR: Small size tartrate-modified, nano-disperse ferrihydrite was used for efficient gastrointestinal delivery of soluble Fe(III) without the risk for free radical generation in murine models. This method may provide a potentially side effect-free form iron supplementation. Elsevier 2014-10 /pmc/articles/PMC4315135/ /pubmed/24394211 http://dx.doi.org/10.1016/j.nano.2013.12.011 Text en Crown Copyright © 2014 Published by Elsevier Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Original Article
Powell, Jonathan J.
Bruggraber, Sylvaine F.A.
Faria, Nuno
Poots, Lynsey K.
Hondow, Nicole
Pennycook, Timothy J.
Latunde-Dada, Gladys O.
Simpson, Robert J.
Brown, Andy P.
Pereira, Dora I.A.
A nano-disperse ferritin-core mimetic that efficiently corrects anemia without luminal iron redox activity
title A nano-disperse ferritin-core mimetic that efficiently corrects anemia without luminal iron redox activity
title_full A nano-disperse ferritin-core mimetic that efficiently corrects anemia without luminal iron redox activity
title_fullStr A nano-disperse ferritin-core mimetic that efficiently corrects anemia without luminal iron redox activity
title_full_unstemmed A nano-disperse ferritin-core mimetic that efficiently corrects anemia without luminal iron redox activity
title_short A nano-disperse ferritin-core mimetic that efficiently corrects anemia without luminal iron redox activity
title_sort nano-disperse ferritin-core mimetic that efficiently corrects anemia without luminal iron redox activity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315135/
https://www.ncbi.nlm.nih.gov/pubmed/24394211
http://dx.doi.org/10.1016/j.nano.2013.12.011
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