Large transcription units unify copy number variants and common fragile sites arising under replication stress

Copy number variants (CNVs) resulting from genomic deletions and duplications and common fragile sites (CFSs) seen as breaks on metaphase chromosomes are distinct forms of structural chromosome instability precipitated by replication inhibition. Although they share a common induction mechanism, it i...

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Detalles Bibliográficos
Autores principales: Wilson, Thomas E., Arlt, Martin F., Park, So Hae, Rajendran, Sountharia, Paulsen, Michelle, Ljungman, Mats, Glover, Thomas W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315293/
https://www.ncbi.nlm.nih.gov/pubmed/25373142
http://dx.doi.org/10.1101/gr.177121.114

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