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Genome-wide discovery of human splicing branchpoints

During the splicing reaction, the 5′ intron end is joined to the branchpoint nucleotide, selecting the next exon to incorporate into the mature RNA and forming an intron lariat, which is excised. Despite a critical role in gene splicing, the locations and features of human splicing branchpoints are...

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Detalles Bibliográficos
Autores principales: Mercer, Tim R., Clark, Michael B., Andersen, Stacey B., Brunck, Marion E., Haerty, Wilfried, Crawford, Joanna, Taft, Ryan J., Nielsen, Lars K., Dinger, Marcel E., Mattick, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315302/
https://www.ncbi.nlm.nih.gov/pubmed/25561518
http://dx.doi.org/10.1101/gr.182899.114