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Novel Agent Nitidine Chloride Induces Erythroid Differentiation and Apoptosis in CML Cells through c-Myc-miRNAs Axis

The proto-oncogene c-Myc plays critical roles in human malignancies including chronic myeloid leukemia (CML), suggesting that the discovery of specific agents targeting c-Myc would be extremely valuable for CML treatment. Nitidine Chloride (NC), a natural bioactive alkaloid, is suggested to possess...

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Detalles Bibliográficos
Autores principales:	Liu, Na, Li, Peng, Zang, Shaolei, Liu, Qiang, Ma, Daoxin, Sun, Xiulian, Ji, Chunyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315404/ https://www.ncbi.nlm.nih.gov/pubmed/25647305 http://dx.doi.org/10.1371/journal.pone.0116880

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