Discovery, Optimization, and Characterization of Novel D(2) Dopamine Receptor Selective Antagonists

[Image: see text] The D2 dopamine receptor (D2 DAR) is one of the most validated drug targets for neuropsychiatric and endocrine disorders. However, clinically approved drugs targeting D2 DAR display poor selectivity between the D2 and other receptors, especially the D3 DAR. This lack of selectivity...

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Detalles Bibliográficos
Autores principales: Xiao, Jingbo, Free, R. Benjamin, Barnaeva, Elena, Conroy, Jennie L., Doyle, Trevor, Miller, Brittney, Bryant-Genevier, Marthe, Taylor, Mercedes K., Hu, Xin, Dulcey, Andrés E., Southall, Noel, Ferrer, Marc, Titus, Steve, Zheng, Wei, Sibley, David R., Marugan, Juan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315423/
https://www.ncbi.nlm.nih.gov/pubmed/24666157
http://dx.doi.org/10.1021/jm500126s

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315423/
https://www.ncbi.nlm.nih.gov/pubmed/24666157
http://dx.doi.org/10.1021/jm500126s

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