Cargando…

Optimization of caseinate-coated simvastatin-zein nanoparticles: improved bioavailability and modified release characteristics

The current study focuses on utilization of the natural biocompatible polymer zein to formulate simvastatin (SMV) nanoparticles coated with caseinate, to improve solubility and hence bioavailability, and in addition, to modify SMV-release characteristics. This formulation can be utilized for oral or...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahmed, Osama AA, Hosny, Khaled M, Al-Sawahli, Majid M, Fahmy, Usama A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315536/ https://www.ncbi.nlm.nih.gov/pubmed/25670883 http://dx.doi.org/10.2147/DDDT.S76194

Ejemplares similares

Optimized zein nanospheres for improved oral bioavailability of atorvastatin
por: Hashem, Fahima M, et al.
Publicado: (2015)

Zein-alpha lipoic acid-loaded nanoparticles to enhance the oral bioavailability of dapoxetine: optimization and clinical pharmacokinetic evaluation
por: El-Say, Khalid M, et al.
Publicado: (2019)

Encapsulation of Lovastatin in Zein Nanoparticles Exhibits Enhanced Apoptotic Activity in HepG2 Cells
por: Alhakamy, Nabil A., et al.
Publicado: (2019)

Custom fractional factorial designs to develop atorvastatin self-nanoemulsifying and nanosuspension delivery systems – enhancement of oral bioavailability
por: Hashem, Fahima M, et al.
Publicado: (2015)

Curcumin encapsulated zein/caseinate-alginate nanoparticles: Release and antioxidant activity under in vitro simulated gastrointestinal digestion
por: Huang, Yunfei, et al.
Publicado: (2023)

Zein Nanoparticles Improve the Oral Bioavailability of Curcumin in Wistar Rats
por: Brotons-Canto, Ana, et al.
Publicado: (2021)

Antimicrobial properties of dental cements modified with zein-coated magnesium oxide nanoparticles
por: Naguib, Ghada H., et al.
Publicado: (2021)

Preparation, characterisation and antioxidant activities of rutin-loaded zein-sodium caseinate nanoparticles
por: Zhang, Shuangling, et al.
Publicado: (2018)

Alendronate Sodium as Enteric Coated Solid Lipid Nanoparticles; Preparation, Optimization, and In Vivo Evaluation to Enhance Its Oral Bioavailability
por: Hosny, Khaled Mohamed
Publicado: (2016)

Optimization of carvedilol solid lipid nanoparticles: An approach to control the release and enhance the oral bioavailability on rabbits
por: El-Say, Khalid Mohamed, et al.
Publicado: (2018)

Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate
por: Li, Feng, et al.
Publicado: (2017)

Enhanced Stability and Oral Bioavailability of Cannabidiol in Zein and Whey Protein Composite Nanoparticles by a Modified Anti-Solvent Approach
por: Wang, Ce, et al.
Publicado: (2022)

Increased Oral Bioavailability of Resveratrol by Its Encapsulation in Casein Nanoparticles
por: Peñalva, Rebeca, et al.
Publicado: (2018)

Preparation and Characterization of Carvacrol-Loaded Caseinate/Zein-Composite Nanoparticles Using the Anti-Solvent Precipitation Method
por: Zheng, Huaming, et al.
Publicado: (2022)

Encapsulation of vitexin-rhamnoside based on zein/pectin nanoparticles improved its stability and bioavailability
por: Huang, Xin, et al.
Publicado: (2022)

Fabrication and Characterization of Zein Composite Particles Coated by Caseinate-Pectin Electrostatic Complexes with Improved Structural Stability in Acidic Aqueous Environments
por: Zhang, Yaqiong, et al.
Publicado: (2019)

Tremella polysaccharides-coated zein nanoparticles for enhancing stability and bioaccessibility of curcumin
por: Li, Duoduo, et al.
Publicado: (2022)

Glucose-Modified Zein Nanoparticles Enhance Oral Delivery of Docetaxel
por: Xing, Yabing, et al.
Publicado: (2022)

Modulation of the fate of zein nanoparticles by their coating with a Gantrez® AN-thiamine polymer conjugate
por: Inchaurraga, Laura, et al.
Publicado: (2019)

Chitosan Coated Microparticles Enhance Simvastatin Colon Targeting and Pro-Apoptotic Activity
por: Alhakamy, Nabil A., et al.
Publicado: (2020)

Quantification of simvastatin in mice plasma by near-infrared and chemometric analysis of spectral data
por: Fahmy, Usama A
Publicado: (2016)

Fabrication and optimization of itraconazole-loaded zein-based nanoparticles in coated capsules as a promising colon-targeting approach pursuing opportunistic fungal infections
por: Adel, Shery, et al.
Publicado: (2023)

Intensification of resveratrol cytotoxicity, pro-apoptosis, oxidant potentials in human colorectal carcinoma HCT-116 cells using zein nanoparticles
por: Khayat, Maan T., et al.
Publicado: (2022)

pH‐driven entrapment of enrofloxacin in casein‐based nanoparticles for the enhancement of oral bioavailability
por: Yuan, Zhi‐xiang, et al.
Publicado: (2021)

In vitro Investigation of the Antimicrobial Activity of Mouth Washes Incorporating Zein-Coated Magnesium Oxide Nanoparticles
por: Naguib, Ghada H, et al.
Publicado: (2021)

Oxidized Dextran as a Macromolecular Crosslinker Stabilizes the Zein/Caseinate Nanocomplex for the Potential Oral Delivery of Curcumin
por: Rodriguez, Nikolas J., et al.
Publicado: (2019)

Surface-Tailored Zein Nanoparticles: Strategies and Applications
por: Abdelsalam, Ahmed M., et al.
Publicado: (2021)

Mechanistic analysis of Zein nanoparticles/PLGA triblock in situ forming implants for glimepiride
por: Ahmed, Osama Abdelhakim Aly, et al.
Publicado: (2016)

Polysaccharide-Zein Composite Nanoparticles for Enhancing Cellular Uptake and Oral Bioavailability of Curcumin: Characterization, Anti-colorectal Cancer Effect, and Pharmacokinetics
por: Liu, Lu, et al.
Publicado: (2022)

Nanoparticles Obtained from Zein for Encapsulation of Mesalazine
por: Lima, Izabela Borges C., et al.
Publicado: (2022)

Fabrication of zein-modified starch nanoparticle complexes via microfluidic chip and encapsulation of nisin
por: Liu, Xuanbo, et al.
Publicado: (2022)

Miconazole-loaded solid lipid nanoparticles: formulation and evaluation of a novel formula with high bioavailability and antifungal activity
por: Aljaeid, Bader Mubarak, et al.
Publicado: (2016)

Improvement of fluvastatin bioavailability by loading on nanostructured lipid carriers
por: El-Helw, Abdel-Rahim M, et al.
Publicado: (2015)

Zein-Stabilized Nanospheres as Nanocarriers for Boosting the Aphrodisiac Activity of Icariin: Response Surface Optimization and In Vivo Assessment
por: Asfour, Hani Z., et al.
Publicado: (2022)

Zein Microparticles and Nanoparticles as Drug Delivery Systems
por: De Marco, Iolanda
Publicado: (2022)

PEG Conjugated Zein Nanoparticles for In Vivo Use
por: van Ballegooie, Courtney, et al.
Publicado: (2022)

Etodolac Fortified Sodium Deoxycholate Stabilized Zein Nanoplatforms for Augmented Repositioning Profile in Human Hepatocellular Carcinoma: Assessment of Bioaccessibility, Anti-Proliferation, Pro-Apoptosis and Oxidant Potentials in HepG2 Cells
por: Kammoun, Ahmed K., et al.
Publicado: (2022)

The Interaction between Zein and Lecithin in Ethanol-Water Solution and Characterization of Zein–Lecithin Composite Colloidal Nanoparticles
por: Dai, Lei, et al.
Publicado: (2016)

Bovine Serum Albumin-Coated Niclosamide-Zein Nanoparticles as Potential Injectable Medicine against COVID-19
por: Rejinold N, Sanoj, et al.
Publicado: (2021)

Development and Characterization of Zein/Ag-Sr Doped Mesoporous Bioactive Glass Nanoparticles Coatings for Biomedical Applications
por: Batool, Syeda Ammara, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ejja1ijk69f2t1m9h6k19rkjbe