The Role of Abcb5 Alleles in Susceptibility to Haloperidol-Induced Toxicity in Mice and Humans

BACKGROUND: We know very little about the genetic factors affecting susceptibility to drug-induced central nervous system (CNS) toxicities, and this has limited our ability to optimally utilize existing drugs or to develop new drugs for CNS disorders. For example, haloperidol is a potent dopamine an...

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Detalles Bibliográficos
Autores principales: Zheng, Ming, Zhang, Haili, Dill, David L., Clark, J. David, Tu, Susan, Yablonovitch, Arielle L., Tan, Meng How, Zhang, Rui, Rujescu, Dan, Wu, Manhong, Tessarollo, Lino, Vieira, Wilfred, Gottesman, Michael M., Deng, Suhua, Eberlin, Livia S., Zare, Richard N., Billard, Jean-Martin, Gillet, Jean-Pierre, Li, Jin Billy, Peltz, Gary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315575/
https://www.ncbi.nlm.nih.gov/pubmed/25647612
http://dx.doi.org/10.1371/journal.pmed.1001782

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