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A1M/α(1)-microglobulin is proteolytically activated by myeloperoxidase, binds its heme group and inhibits low density lipoprotein oxidation

α(1)-microglobulin (A1M) is a 26 kDa plasma and tissue protein with reductase activity and radical- and heme-binding anti-oxidative functions. In addition, exposure of A1M to hemoglobin has been shown to induce proteolytic elimination of a C-terminal tetrapeptide yielding a heme-degrading form, trun...

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Detalles Bibliográficos
Autores principales:	Cederlund, Martin, Deronic, Adnan, Pallon, Jan, Sørensen, Ole E., Åkerström, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315848/ https://www.ncbi.nlm.nih.gov/pubmed/25698971 http://dx.doi.org/10.3389/fphys.2015.00011

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