Reduced TET2 function leads to T-cell lymphoma with follicular helper T-cell-like features in mice

TET2 (Ten Eleven Translocation 2) is a dioxygenase that converts methylcytosine (mC) to hydroxymethylcytosine (hmC). TET2 loss-of-function mutations are highly frequent in subtypes of T-cell lymphoma that harbor follicular helper T (Tfh)-cell-like features, such as angioimmunoblastic T-cell lymphoma...

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Detalles Bibliográficos
Autores principales: Muto, H, Sakata-Yanagimoto, M, Nagae, G, Shiozawa, Y, Miyake, Y, Yoshida, K, Enami, T, Kamada, Y, Kato, T, Uchida, K, Nanmoku, T, Obara, N, Suzukawa, K, Sanada, M, Nakamura, N, Aburatani, H, Ogawa, S, Chiba, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315889/
https://www.ncbi.nlm.nih.gov/pubmed/25501021
http://dx.doi.org/10.1038/bcj.2014.83

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