Ezh2 mediated H3K27me3 activity facilitates somatic transition during human pluripotent reprogramming

Factor induced reprogramming of fibroblasts is an orchestrated but inefficient process. At the epigenetic level, it results in drastic chromatin changes to erase the existing somatic “memory” and to establish the pluripotent state. Accordingly, alterations of chromatin regulators including Ezh2 infl...

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Detalles Bibliográficos
Autores principales: Rao, Radhika Arasala, Dhele, Narendra, Cheemadan, Sabna, Ketkar, Alhad, Jayandharan, Giridhara R., Palakodeti, Dasaradhi, Rampalli, Shravanti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316165/
https://www.ncbi.nlm.nih.gov/pubmed/25648270
http://dx.doi.org/10.1038/srep08229

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