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Serum lipid profiles and glycemic control in adolescents and young adults with type 1 diabetes mellitus

PURPOSE: We aimed to investigate serum lipid profiles and glycemic control in adolescents and young adults with type 1diabetes mellitus (T1DM). METHODS: This cross-sectional study included 29 Korean young adults and adolescents with T1DM. The median age was 17 years (range, 10-25 years) and 18 (62.1...

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Autores principales: Kim, Shin-Hee, Jung, In-Ah, Jeon, Yeon Jin, Cho, Won Kyoung, Cho, Kyoung Soon, Park, So Hyun, Jung, Min Ho, Suh, Byoung Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Pediatric Endocrinology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316412/
https://www.ncbi.nlm.nih.gov/pubmed/25654064
http://dx.doi.org/10.6065/apem.2014.19.4.191
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author Kim, Shin-Hee
Jung, In-Ah
Jeon, Yeon Jin
Cho, Won Kyoung
Cho, Kyoung Soon
Park, So Hyun
Jung, Min Ho
Suh, Byoung Kyu
author_facet Kim, Shin-Hee
Jung, In-Ah
Jeon, Yeon Jin
Cho, Won Kyoung
Cho, Kyoung Soon
Park, So Hyun
Jung, Min Ho
Suh, Byoung Kyu
author_sort Kim, Shin-Hee
collection PubMed
description PURPOSE: We aimed to investigate serum lipid profiles and glycemic control in adolescents and young adults with type 1diabetes mellitus (T1DM). METHODS: This cross-sectional study included 29 Korean young adults and adolescents with T1DM. The median age was 17 years (range, 10-25 years) and 18 (62.1%) were female. We compared the lipid profiles of patients with dyslipidemia and those without dyslipidemia. Correlations between glycosylated hemoglobin (HbA1c) and lipid profiles (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], and triglyceride [TG]) were determined by linear regression analysis. RESULTS: Of the 29 patients with T1DM, 11 (37.9%) were classified as having dyslipidemia due to the following lipid abnormality: TC≥200 mg/dL in 8 patients, LDL-C≥130 mg/dL in 4 patients, TG≥150 mg/dL in 2 patients, and HDL-C≤35 mg/dL in 2 patients. Compared to patients without dyslipidemia, patients with dyslipidemia were more likely to have higher values of HbA1c (median, 10.6%; range, 7.5%-12.3% vs. median, 8.0%; range, 6.6%-10.0%; P=0.002) and a higher body mass index z score (median, 0.7; range, -0.57 to 2.6 vs. median, -0.4; range, -2.5 to 2.2; P=0.02). HbA1c levels were positively correlated with TC (P=0.03, R(2)=0.156) and TG (P=0.005, R(2)=0.261). CONCLUSION: A substantial proportion of adolescents and young adults with T1DM had dyslipidemia. We found a correlation between poor glycemic control and poor lipid profiles in those patients.
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spelling pubmed-43164122015-02-04 Serum lipid profiles and glycemic control in adolescents and young adults with type 1 diabetes mellitus Kim, Shin-Hee Jung, In-Ah Jeon, Yeon Jin Cho, Won Kyoung Cho, Kyoung Soon Park, So Hyun Jung, Min Ho Suh, Byoung Kyu Ann Pediatr Endocrinol Metab Original Article PURPOSE: We aimed to investigate serum lipid profiles and glycemic control in adolescents and young adults with type 1diabetes mellitus (T1DM). METHODS: This cross-sectional study included 29 Korean young adults and adolescents with T1DM. The median age was 17 years (range, 10-25 years) and 18 (62.1%) were female. We compared the lipid profiles of patients with dyslipidemia and those without dyslipidemia. Correlations between glycosylated hemoglobin (HbA1c) and lipid profiles (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], and triglyceride [TG]) were determined by linear regression analysis. RESULTS: Of the 29 patients with T1DM, 11 (37.9%) were classified as having dyslipidemia due to the following lipid abnormality: TC≥200 mg/dL in 8 patients, LDL-C≥130 mg/dL in 4 patients, TG≥150 mg/dL in 2 patients, and HDL-C≤35 mg/dL in 2 patients. Compared to patients without dyslipidemia, patients with dyslipidemia were more likely to have higher values of HbA1c (median, 10.6%; range, 7.5%-12.3% vs. median, 8.0%; range, 6.6%-10.0%; P=0.002) and a higher body mass index z score (median, 0.7; range, -0.57 to 2.6 vs. median, -0.4; range, -2.5 to 2.2; P=0.02). HbA1c levels were positively correlated with TC (P=0.03, R(2)=0.156) and TG (P=0.005, R(2)=0.261). CONCLUSION: A substantial proportion of adolescents and young adults with T1DM had dyslipidemia. We found a correlation between poor glycemic control and poor lipid profiles in those patients. The Korean Society of Pediatric Endocrinology 2014-12 2014-12-31 /pmc/articles/PMC4316412/ /pubmed/25654064 http://dx.doi.org/10.6065/apem.2014.19.4.191 Text en © 2014 Annals of Pediatric Endocrinology & Metabolism http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Shin-Hee
Jung, In-Ah
Jeon, Yeon Jin
Cho, Won Kyoung
Cho, Kyoung Soon
Park, So Hyun
Jung, Min Ho
Suh, Byoung Kyu
Serum lipid profiles and glycemic control in adolescents and young adults with type 1 diabetes mellitus
title Serum lipid profiles and glycemic control in adolescents and young adults with type 1 diabetes mellitus
title_full Serum lipid profiles and glycemic control in adolescents and young adults with type 1 diabetes mellitus
title_fullStr Serum lipid profiles and glycemic control in adolescents and young adults with type 1 diabetes mellitus
title_full_unstemmed Serum lipid profiles and glycemic control in adolescents and young adults with type 1 diabetes mellitus
title_short Serum lipid profiles and glycemic control in adolescents and young adults with type 1 diabetes mellitus
title_sort serum lipid profiles and glycemic control in adolescents and young adults with type 1 diabetes mellitus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316412/
https://www.ncbi.nlm.nih.gov/pubmed/25654064
http://dx.doi.org/10.6065/apem.2014.19.4.191
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