Melatonin lowers edema after spinal cord injury

Melatonin has been shown to diminish edema in rats. Melatonin can be used to treat spinal cord injury. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg/kg, i.p.) could reduce the water content of the spinal...

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Detalles Bibliográficos
Autores principales: Li, Cheng, Chen, Xiao, Qiao, Suchi, Liu, Xinwei, Liu, Chang, Zhu, Degang, Su, Jiacan, Wang, Zhiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Research and Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316455/
https://www.ncbi.nlm.nih.gov/pubmed/25657743
http://dx.doi.org/10.4103/1673-5374.147954
Descripción
Sumario:Melatonin has been shown to diminish edema in rats. Melatonin can be used to treat spinal cord injury. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg/kg, i.p.) could reduce the water content of the spinal cord, and suppress the expression of aquaporin-4 and glial fibrillary acidic protein after spinal cord injury. This suggests that the mechanism by which melatonin alleviates the damage to the spinal cord by edema might be related to the expression of aquaporin-4 and glial fibrillary acidic protein.

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