Melatonin lowers edema after spinal cord injury

Melatonin has been shown to diminish edema in rats. Melatonin can be used to treat spinal cord injury. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg/kg, i.p.) could reduce the water content of the spinal...

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Detalles Bibliográficos
Autores principales: Li, Cheng, Chen, Xiao, Qiao, Suchi, Liu, Xinwei, Liu, Chang, Zhu, Degang, Su, Jiacan, Wang, Zhiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Research and Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316455/
https://www.ncbi.nlm.nih.gov/pubmed/25657743
http://dx.doi.org/10.4103/1673-5374.147954
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author Li, Cheng
Chen, Xiao
Qiao, Suchi
Liu, Xinwei
Liu, Chang
Zhu, Degang
Su, Jiacan
Wang, Zhiwei
author_facet Li, Cheng
Chen, Xiao
Qiao, Suchi
Liu, Xinwei
Liu, Chang
Zhu, Degang
Su, Jiacan
Wang, Zhiwei
author_sort Li, Cheng
collection PubMed
description Melatonin has been shown to diminish edema in rats. Melatonin can be used to treat spinal cord injury. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg/kg, i.p.) could reduce the water content of the spinal cord, and suppress the expression of aquaporin-4 and glial fibrillary acidic protein after spinal cord injury. This suggests that the mechanism by which melatonin alleviates the damage to the spinal cord by edema might be related to the expression of aquaporin-4 and glial fibrillary acidic protein.
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spelling pubmed-43164552015-02-05 Melatonin lowers edema after spinal cord injury Li, Cheng Chen, Xiao Qiao, Suchi Liu, Xinwei Liu, Chang Zhu, Degang Su, Jiacan Wang, Zhiwei Neural Regen Res Research and Report Melatonin has been shown to diminish edema in rats. Melatonin can be used to treat spinal cord injury. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg/kg, i.p.) could reduce the water content of the spinal cord, and suppress the expression of aquaporin-4 and glial fibrillary acidic protein after spinal cord injury. This suggests that the mechanism by which melatonin alleviates the damage to the spinal cord by edema might be related to the expression of aquaporin-4 and glial fibrillary acidic protein. Medknow Publications & Media Pvt Ltd 2014-12-15 /pmc/articles/PMC4316455/ /pubmed/25657743 http://dx.doi.org/10.4103/1673-5374.147954 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report
Li, Cheng
Chen, Xiao
Qiao, Suchi
Liu, Xinwei
Liu, Chang
Zhu, Degang
Su, Jiacan
Wang, Zhiwei
Melatonin lowers edema after spinal cord injury
title Melatonin lowers edema after spinal cord injury
title_full Melatonin lowers edema after spinal cord injury
title_fullStr Melatonin lowers edema after spinal cord injury
title_full_unstemmed Melatonin lowers edema after spinal cord injury
title_short Melatonin lowers edema after spinal cord injury
title_sort melatonin lowers edema after spinal cord injury
topic Research and Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316455/
https://www.ncbi.nlm.nih.gov/pubmed/25657743
http://dx.doi.org/10.4103/1673-5374.147954
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