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Antigen-driven focal inflammatory death of malaria liver stages

Multiple immunizations using live irradiated sporozoites, the infectious plasmodial stage delivered into the host skin during a mosquito bite, can elicit sterile immunity to malaria. CD8(+) T cells seem to play an essential role in this protective immunity, since their depletion consistently abolish...

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Autores principales: Bayarsaikhan, Ganchimeg, Akbari, Masoud, Yui, Katsuyuki, Amino, Rogerio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316770/
https://www.ncbi.nlm.nih.gov/pubmed/25699034
http://dx.doi.org/10.3389/fmicb.2015.00047
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author Bayarsaikhan, Ganchimeg
Akbari, Masoud
Yui, Katsuyuki
Amino, Rogerio
author_facet Bayarsaikhan, Ganchimeg
Akbari, Masoud
Yui, Katsuyuki
Amino, Rogerio
author_sort Bayarsaikhan, Ganchimeg
collection PubMed
description Multiple immunizations using live irradiated sporozoites, the infectious plasmodial stage delivered into the host skin during a mosquito bite, can elicit sterile immunity to malaria. CD8(+) T cells seem to play an essential role in this protective immunity, since their depletion consistently abolishes sterilizing protection in several experimental models. So far, only a few parasite antigens are known to induce CD8(+) T cell-dependent protection, but none of them can reach the levels of protection afforded by live attenuated parasites. Systematic attempts to identify novel antigens associated with this efficient cellular protection were so far unsuccessful. In addition, the precise mechanisms involved in the recognition and elimination of parasitized hepatocytes in vivo by CD8(+) T cells still remain obscure. Recently, it has been shown that specific effector CD8(+) T cells, after recognition of parasitized hepatocytes, recruit specific and non-specific activated CD8(+) T cells to the site of infection, resulting in the formation of cellular clusters around and in the further elimination of intracellular parasites. The significance of this finding is discussed in the perspective of a general mechanism of antigen-dependent focalized inflammation and its consequences for the elimination of malaria liver stages.
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spelling pubmed-43167702015-02-19 Antigen-driven focal inflammatory death of malaria liver stages Bayarsaikhan, Ganchimeg Akbari, Masoud Yui, Katsuyuki Amino, Rogerio Front Microbiol Immunology Multiple immunizations using live irradiated sporozoites, the infectious plasmodial stage delivered into the host skin during a mosquito bite, can elicit sterile immunity to malaria. CD8(+) T cells seem to play an essential role in this protective immunity, since their depletion consistently abolishes sterilizing protection in several experimental models. So far, only a few parasite antigens are known to induce CD8(+) T cell-dependent protection, but none of them can reach the levels of protection afforded by live attenuated parasites. Systematic attempts to identify novel antigens associated with this efficient cellular protection were so far unsuccessful. In addition, the precise mechanisms involved in the recognition and elimination of parasitized hepatocytes in vivo by CD8(+) T cells still remain obscure. Recently, it has been shown that specific effector CD8(+) T cells, after recognition of parasitized hepatocytes, recruit specific and non-specific activated CD8(+) T cells to the site of infection, resulting in the formation of cellular clusters around and in the further elimination of intracellular parasites. The significance of this finding is discussed in the perspective of a general mechanism of antigen-dependent focalized inflammation and its consequences for the elimination of malaria liver stages. Frontiers Media S.A. 2015-02-04 /pmc/articles/PMC4316770/ /pubmed/25699034 http://dx.doi.org/10.3389/fmicb.2015.00047 Text en Copyright © 2015 Bayarsaikhan, Akbari, Yui and Amino. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Bayarsaikhan, Ganchimeg
Akbari, Masoud
Yui, Katsuyuki
Amino, Rogerio
Antigen-driven focal inflammatory death of malaria liver stages
title Antigen-driven focal inflammatory death of malaria liver stages
title_full Antigen-driven focal inflammatory death of malaria liver stages
title_fullStr Antigen-driven focal inflammatory death of malaria liver stages
title_full_unstemmed Antigen-driven focal inflammatory death of malaria liver stages
title_short Antigen-driven focal inflammatory death of malaria liver stages
title_sort antigen-driven focal inflammatory death of malaria liver stages
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316770/
https://www.ncbi.nlm.nih.gov/pubmed/25699034
http://dx.doi.org/10.3389/fmicb.2015.00047
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