Selection of IgG Variants with Increased FcRn Binding Using Random and Directed Mutagenesis: Impact on Effector Functions

Despite the reasonably long half-life of immunoglogulin G (IgGs), market pressure for higher patient convenience while conserving efficacy continues to drive IgG half-life improvement. IgG half-life is dependent on the neonatal Fc receptor (FcRn), which among other functions, protects IgG from catab...

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Detalles Bibliográficos
Autores principales: Monnet, Céline, Jorieux, Sylvie, Urbain, Rémi, Fournier, Nathalie, Bouayadi, Khalil, De Romeuf, Christophe, Behrens, Christian K., Fontayne, Alexandre, Mondon, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316771/
https://www.ncbi.nlm.nih.gov/pubmed/25699055
http://dx.doi.org/10.3389/fimmu.2015.00039

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