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The dehydrogenase region of the NADPH oxidase component Nox2 acts as a protein disulfide isomerase (PDI) resembling PDIA3 with a role in the binding of the activator protein p67(phox)

The superoxide (O(·−)(2))-generating NADPH oxidase of phagocytes consists of a membrane component, cytochrome b(558) (a heterodimer of Nox2 and p22(phox)), and four cytosolic components, p47(phox), p67(phox), p40(phox), and Rac. The catalytic component, responsible for O(·−)(2) generation, is Nox2....

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Detalles Bibliográficos
Autores principales:	Bechor, Edna, Dahan, Iris, Fradin, Tanya, Berdichevsky, Yevgeny, Zahavi, Anat, Federman Gross, Aya, Rafalowski, Meirav, Pick, Edgar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316792/ https://www.ncbi.nlm.nih.gov/pubmed/25699251 http://dx.doi.org/10.3389/fchem.2015.00003

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