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Inter-study reproducibility of interleaved spiral phase velocity mapping of renal artery haemodynamics

BACKGROUND: Qualitative and quantitative assessment of renal blood flow is valuable in the evaluation of patients with renal and renovascular diseases as well as in patients with heart failure. The temporal pattern of renal flow velocity through the cardiac cycle provides important information about...

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Autores principales: Keegan, Jennifer, Patel, Hitesh C, Simpson, Robin M, Mohiaddin, Raad H, Firmin, David N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316806/
https://www.ncbi.nlm.nih.gov/pubmed/25648103
http://dx.doi.org/10.1186/s12968-014-0105-x
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author Keegan, Jennifer
Patel, Hitesh C
Simpson, Robin M
Mohiaddin, Raad H
Firmin, David N
author_facet Keegan, Jennifer
Patel, Hitesh C
Simpson, Robin M
Mohiaddin, Raad H
Firmin, David N
author_sort Keegan, Jennifer
collection PubMed
description BACKGROUND: Qualitative and quantitative assessment of renal blood flow is valuable in the evaluation of patients with renal and renovascular diseases as well as in patients with heart failure. The temporal pattern of renal flow velocity through the cardiac cycle provides important information about renal haemodynamics. High temporal resolution interleaved spiral phase velocity mapping could potentially be used to study temporal patterns of flow and measure resistive and pulsatility indices which are measures of downstream resistance. METHODS: A retrospectively gated breath-hold spiral phase velocity mapping sequence (TR 19 ms) was developed at 3 Tesla. Phase velocity maps were acquired in the proximal right and left arteries of 10 healthy subjects in each of two separate scanning sessions. Each acquisition was analysed by two independent observers who calculated the resistive index (RI), the pulsatility index (PI), the mean flow velocity and the renal artery blood flow (RABF). Inter-study and inter-observer reproducibility of each variable was determined as the mean +/− standard deviation of the differences between paired values. The effect of background phase errors on each parameter was investigated. RESULTS: RI, PI, mean velocity and RABF per kidney were 0.71+/− 0.06, 1.47 +/− 0.29, 253.5 +/− 65.2 mm/s and 413 +/− 122 ml/min respectively. The inter-study reproducibilities were: RI −0.00 +/− 0.04 , PI −0.03 +/− 0.17, mean velocity −6.7 +/− 31.1 mm/s and RABF per kidney 17.9 +/− 44.8 ml/min. The effect of background phase errors was negligible (<2% for each parameter). CONCLUSIONS: High temporal resolution breath-hold spiral phase velocity mapping allows reproducible assessment of renal pulsatility indices and RABF.
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spelling pubmed-43168062015-02-05 Inter-study reproducibility of interleaved spiral phase velocity mapping of renal artery haemodynamics Keegan, Jennifer Patel, Hitesh C Simpson, Robin M Mohiaddin, Raad H Firmin, David N J Cardiovasc Magn Reson Research BACKGROUND: Qualitative and quantitative assessment of renal blood flow is valuable in the evaluation of patients with renal and renovascular diseases as well as in patients with heart failure. The temporal pattern of renal flow velocity through the cardiac cycle provides important information about renal haemodynamics. High temporal resolution interleaved spiral phase velocity mapping could potentially be used to study temporal patterns of flow and measure resistive and pulsatility indices which are measures of downstream resistance. METHODS: A retrospectively gated breath-hold spiral phase velocity mapping sequence (TR 19 ms) was developed at 3 Tesla. Phase velocity maps were acquired in the proximal right and left arteries of 10 healthy subjects in each of two separate scanning sessions. Each acquisition was analysed by two independent observers who calculated the resistive index (RI), the pulsatility index (PI), the mean flow velocity and the renal artery blood flow (RABF). Inter-study and inter-observer reproducibility of each variable was determined as the mean +/− standard deviation of the differences between paired values. The effect of background phase errors on each parameter was investigated. RESULTS: RI, PI, mean velocity and RABF per kidney were 0.71+/− 0.06, 1.47 +/− 0.29, 253.5 +/− 65.2 mm/s and 413 +/− 122 ml/min respectively. The inter-study reproducibilities were: RI −0.00 +/− 0.04 , PI −0.03 +/− 0.17, mean velocity −6.7 +/− 31.1 mm/s and RABF per kidney 17.9 +/− 44.8 ml/min. The effect of background phase errors was negligible (<2% for each parameter). CONCLUSIONS: High temporal resolution breath-hold spiral phase velocity mapping allows reproducible assessment of renal pulsatility indices and RABF. BioMed Central 2015-02-04 /pmc/articles/PMC4316806/ /pubmed/25648103 http://dx.doi.org/10.1186/s12968-014-0105-x Text en © Keegan et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Keegan, Jennifer
Patel, Hitesh C
Simpson, Robin M
Mohiaddin, Raad H
Firmin, David N
Inter-study reproducibility of interleaved spiral phase velocity mapping of renal artery haemodynamics
title Inter-study reproducibility of interleaved spiral phase velocity mapping of renal artery haemodynamics
title_full Inter-study reproducibility of interleaved spiral phase velocity mapping of renal artery haemodynamics
title_fullStr Inter-study reproducibility of interleaved spiral phase velocity mapping of renal artery haemodynamics
title_full_unstemmed Inter-study reproducibility of interleaved spiral phase velocity mapping of renal artery haemodynamics
title_short Inter-study reproducibility of interleaved spiral phase velocity mapping of renal artery haemodynamics
title_sort inter-study reproducibility of interleaved spiral phase velocity mapping of renal artery haemodynamics
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316806/
https://www.ncbi.nlm.nih.gov/pubmed/25648103
http://dx.doi.org/10.1186/s12968-014-0105-x
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