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Diffuse lung disease of infancy: a pattern-based, algorithmic approach to histological diagnosis

Diffuse lung disease (DLD) of infancy has multiple aetiologies and the spectrum of disease is substantially different from that seen in older children and adults. In many cases, a specific diagnosis renders a dire prognosis for the infant, with profound management implications. Two recently publishe...

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Autores principales: Armes, Jane E, Mifsud, William, Ashworth, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316934/
https://www.ncbi.nlm.nih.gov/pubmed/25477529
http://dx.doi.org/10.1136/jclinpath-2014-202685
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author Armes, Jane E
Mifsud, William
Ashworth, Michael
author_facet Armes, Jane E
Mifsud, William
Ashworth, Michael
author_sort Armes, Jane E
collection PubMed
description Diffuse lung disease (DLD) of infancy has multiple aetiologies and the spectrum of disease is substantially different from that seen in older children and adults. In many cases, a specific diagnosis renders a dire prognosis for the infant, with profound management implications. Two recently published series of DLD of infancy, collated from the archives of specialist centres, indicate that the majority of their cases were referred, implying that the majority of biopsies taken for DLD of infancy are first received by less experienced pathologists. The current literature describing DLD of infancy takes a predominantly aetiological approach to classification. We present an algorithmic, histological, pattern-based approach to diagnosis of DLD of infancy, which, with the aid of appropriate multidisciplinary input, including clinical and radiological expertise and ancillary diagnostic studies, may lead to an accurate and useful interim report, with timely exclusion of inappropriate diagnoses. Subsequent referral to a specialist centre for confirmatory diagnosis will be dependent on the individual case and the decision of the multidisciplinary team.
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spelling pubmed-43169342015-02-11 Diffuse lung disease of infancy: a pattern-based, algorithmic approach to histological diagnosis Armes, Jane E Mifsud, William Ashworth, Michael J Clin Pathol Review Diffuse lung disease (DLD) of infancy has multiple aetiologies and the spectrum of disease is substantially different from that seen in older children and adults. In many cases, a specific diagnosis renders a dire prognosis for the infant, with profound management implications. Two recently published series of DLD of infancy, collated from the archives of specialist centres, indicate that the majority of their cases were referred, implying that the majority of biopsies taken for DLD of infancy are first received by less experienced pathologists. The current literature describing DLD of infancy takes a predominantly aetiological approach to classification. We present an algorithmic, histological, pattern-based approach to diagnosis of DLD of infancy, which, with the aid of appropriate multidisciplinary input, including clinical and radiological expertise and ancillary diagnostic studies, may lead to an accurate and useful interim report, with timely exclusion of inappropriate diagnoses. Subsequent referral to a specialist centre for confirmatory diagnosis will be dependent on the individual case and the decision of the multidisciplinary team. BMJ Publishing Group 2015-02 2014-12-04 /pmc/articles/PMC4316934/ /pubmed/25477529 http://dx.doi.org/10.1136/jclinpath-2014-202685 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Review
Armes, Jane E
Mifsud, William
Ashworth, Michael
Diffuse lung disease of infancy: a pattern-based, algorithmic approach to histological diagnosis
title Diffuse lung disease of infancy: a pattern-based, algorithmic approach to histological diagnosis
title_full Diffuse lung disease of infancy: a pattern-based, algorithmic approach to histological diagnosis
title_fullStr Diffuse lung disease of infancy: a pattern-based, algorithmic approach to histological diagnosis
title_full_unstemmed Diffuse lung disease of infancy: a pattern-based, algorithmic approach to histological diagnosis
title_short Diffuse lung disease of infancy: a pattern-based, algorithmic approach to histological diagnosis
title_sort diffuse lung disease of infancy: a pattern-based, algorithmic approach to histological diagnosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316934/
https://www.ncbi.nlm.nih.gov/pubmed/25477529
http://dx.doi.org/10.1136/jclinpath-2014-202685
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