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Diffuse lung disease of infancy: a pattern-based, algorithmic approach to histological diagnosis
Diffuse lung disease (DLD) of infancy has multiple aetiologies and the spectrum of disease is substantially different from that seen in older children and adults. In many cases, a specific diagnosis renders a dire prognosis for the infant, with profound management implications. Two recently publishe...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316934/ https://www.ncbi.nlm.nih.gov/pubmed/25477529 http://dx.doi.org/10.1136/jclinpath-2014-202685 |
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author | Armes, Jane E Mifsud, William Ashworth, Michael |
author_facet | Armes, Jane E Mifsud, William Ashworth, Michael |
author_sort | Armes, Jane E |
collection | PubMed |
description | Diffuse lung disease (DLD) of infancy has multiple aetiologies and the spectrum of disease is substantially different from that seen in older children and adults. In many cases, a specific diagnosis renders a dire prognosis for the infant, with profound management implications. Two recently published series of DLD of infancy, collated from the archives of specialist centres, indicate that the majority of their cases were referred, implying that the majority of biopsies taken for DLD of infancy are first received by less experienced pathologists. The current literature describing DLD of infancy takes a predominantly aetiological approach to classification. We present an algorithmic, histological, pattern-based approach to diagnosis of DLD of infancy, which, with the aid of appropriate multidisciplinary input, including clinical and radiological expertise and ancillary diagnostic studies, may lead to an accurate and useful interim report, with timely exclusion of inappropriate diagnoses. Subsequent referral to a specialist centre for confirmatory diagnosis will be dependent on the individual case and the decision of the multidisciplinary team. |
format | Online Article Text |
id | pubmed-4316934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-43169342015-02-11 Diffuse lung disease of infancy: a pattern-based, algorithmic approach to histological diagnosis Armes, Jane E Mifsud, William Ashworth, Michael J Clin Pathol Review Diffuse lung disease (DLD) of infancy has multiple aetiologies and the spectrum of disease is substantially different from that seen in older children and adults. In many cases, a specific diagnosis renders a dire prognosis for the infant, with profound management implications. Two recently published series of DLD of infancy, collated from the archives of specialist centres, indicate that the majority of their cases were referred, implying that the majority of biopsies taken for DLD of infancy are first received by less experienced pathologists. The current literature describing DLD of infancy takes a predominantly aetiological approach to classification. We present an algorithmic, histological, pattern-based approach to diagnosis of DLD of infancy, which, with the aid of appropriate multidisciplinary input, including clinical and radiological expertise and ancillary diagnostic studies, may lead to an accurate and useful interim report, with timely exclusion of inappropriate diagnoses. Subsequent referral to a specialist centre for confirmatory diagnosis will be dependent on the individual case and the decision of the multidisciplinary team. BMJ Publishing Group 2015-02 2014-12-04 /pmc/articles/PMC4316934/ /pubmed/25477529 http://dx.doi.org/10.1136/jclinpath-2014-202685 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Review Armes, Jane E Mifsud, William Ashworth, Michael Diffuse lung disease of infancy: a pattern-based, algorithmic approach to histological diagnosis |
title | Diffuse lung disease of infancy: a pattern-based, algorithmic approach to histological diagnosis |
title_full | Diffuse lung disease of infancy: a pattern-based, algorithmic approach to histological diagnosis |
title_fullStr | Diffuse lung disease of infancy: a pattern-based, algorithmic approach to histological diagnosis |
title_full_unstemmed | Diffuse lung disease of infancy: a pattern-based, algorithmic approach to histological diagnosis |
title_short | Diffuse lung disease of infancy: a pattern-based, algorithmic approach to histological diagnosis |
title_sort | diffuse lung disease of infancy: a pattern-based, algorithmic approach to histological diagnosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316934/ https://www.ncbi.nlm.nih.gov/pubmed/25477529 http://dx.doi.org/10.1136/jclinpath-2014-202685 |
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