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Biocompatibility and osteogenic properties of porous tantalum

Porous tantalum has been reported to be a promising material for use in bone tissue engineering. In the present study, the biocompatibility and osteogenic properties of porous tantalum were studied in vitro and in vivo. The morphology of porous tantalum was observed using scanning electron microscop...

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Autores principales: WANG, QIAN, ZHANG, HUI, LI, QIJIA, YE, LEI, GAN, HONGQUAN, LIU, YINGJIE, WANG, HUI, WANG, ZHIQIANG
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316955/
https://www.ncbi.nlm.nih.gov/pubmed/25667628
http://dx.doi.org/10.3892/etm.2015.2208
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author WANG, QIAN
ZHANG, HUI
LI, QIJIA
YE, LEI
GAN, HONGQUAN
LIU, YINGJIE
WANG, HUI
WANG, ZHIQIANG
author_facet WANG, QIAN
ZHANG, HUI
LI, QIJIA
YE, LEI
GAN, HONGQUAN
LIU, YINGJIE
WANG, HUI
WANG, ZHIQIANG
author_sort WANG, QIAN
collection PubMed
description Porous tantalum has been reported to be a promising material for use in bone tissue engineering. In the present study, the biocompatibility and osteogenic properties of porous tantalum were studied in vitro and in vivo. The morphology of porous tantalum was observed using scanning electron microscopy (SEM). Osteoblasts were cultured with porous tantalum, and cell morphology, adhesion and proliferation were investigated using optical microscopy and SEM. In addition, porous tantalum rods were implanted in rabbits, and osteogenesis was observed using laser scanning confocal microscopy and hard tissue slice examination. The osteoblasts were observed to proliferate over time and adhere to the tantalum surface and pore walls, exhibiting a variety of shapes and intercellular connections. The porous tantalum rod connected tightly with the host bone. At weeks 2 and 4 following implantation, new bone and small blood vessels were observed at the tantalum-host bone interface and pores. At week 10 after the porous tantalum implantation, new bone tissue was observed at the tantalum-host bone interface and pores. By week 12, the tantalum-host bone interface and pores were covered with new bone tissue and the bone trabeculae had matured and connected directly with the materials. Therefore, the results of the present study indicate that porous tantalum is non-toxic, biocompatible and a promising material for use in bone tissue engineering applications.
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spelling pubmed-43169552015-02-09 Biocompatibility and osteogenic properties of porous tantalum WANG, QIAN ZHANG, HUI LI, QIJIA YE, LEI GAN, HONGQUAN LIU, YINGJIE WANG, HUI WANG, ZHIQIANG Exp Ther Med Articles Porous tantalum has been reported to be a promising material for use in bone tissue engineering. In the present study, the biocompatibility and osteogenic properties of porous tantalum were studied in vitro and in vivo. The morphology of porous tantalum was observed using scanning electron microscopy (SEM). Osteoblasts were cultured with porous tantalum, and cell morphology, adhesion and proliferation were investigated using optical microscopy and SEM. In addition, porous tantalum rods were implanted in rabbits, and osteogenesis was observed using laser scanning confocal microscopy and hard tissue slice examination. The osteoblasts were observed to proliferate over time and adhere to the tantalum surface and pore walls, exhibiting a variety of shapes and intercellular connections. The porous tantalum rod connected tightly with the host bone. At weeks 2 and 4 following implantation, new bone and small blood vessels were observed at the tantalum-host bone interface and pores. At week 10 after the porous tantalum implantation, new bone tissue was observed at the tantalum-host bone interface and pores. By week 12, the tantalum-host bone interface and pores were covered with new bone tissue and the bone trabeculae had matured and connected directly with the materials. Therefore, the results of the present study indicate that porous tantalum is non-toxic, biocompatible and a promising material for use in bone tissue engineering applications. D.A. Spandidos 2015-03 2015-01-23 /pmc/articles/PMC4316955/ /pubmed/25667628 http://dx.doi.org/10.3892/etm.2015.2208 Text en Copyright © 2015, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Articles
WANG, QIAN
ZHANG, HUI
LI, QIJIA
YE, LEI
GAN, HONGQUAN
LIU, YINGJIE
WANG, HUI
WANG, ZHIQIANG
Biocompatibility and osteogenic properties of porous tantalum
title Biocompatibility and osteogenic properties of porous tantalum
title_full Biocompatibility and osteogenic properties of porous tantalum
title_fullStr Biocompatibility and osteogenic properties of porous tantalum
title_full_unstemmed Biocompatibility and osteogenic properties of porous tantalum
title_short Biocompatibility and osteogenic properties of porous tantalum
title_sort biocompatibility and osteogenic properties of porous tantalum
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316955/
https://www.ncbi.nlm.nih.gov/pubmed/25667628
http://dx.doi.org/10.3892/etm.2015.2208
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