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A+-Helix of Protein C Inhibitor (PCI) Is a Cell-penetrating Peptide That Mediates Cell Membrane Permeation of PCI
Protein C inhibitor (PCI) is a serpin with broad protease reactivity. It binds glycosaminoglycans and certain phospholipids that can modulate its inhibitory activity. PCI can penetrate through cellular membranes via binding to phosphatidylethanolamine. The exact mechanism of PCI internalization and...
Autores principales: | Yang, Hanjiang, Wahlmüller, Felix Christof, Sarg, Bettina, Furtmüller, Margareta, Geiger, Margarethe |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317013/ https://www.ncbi.nlm.nih.gov/pubmed/25488662 http://dx.doi.org/10.1074/jbc.M114.581736 |
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