Cargando…

Acceleration of α-Synuclein Aggregation by Exosomes

Exosomes are small vesicles released from cells into extracellular space. We have isolated exosomes from neuroblastoma cells and investigated their influence on the aggregation of α-synuclein, a protein associated with Parkinson disease pathology. Using cryo-transmission electron microscopy of exoso...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grey, Marie, Dunning, Christopher J., Gaspar, Ricardo, Grey, Carl, Brundin, Patrik, Sparr, Emma, Linse, Sara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2015
Materias:	Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317028/ https://www.ncbi.nlm.nih.gov/pubmed/25425650 http://dx.doi.org/10.1074/jbc.M114.585703

Ejemplares similares

Ganglioside lipids accelerate α-synuclein amyloid formation
por: Gaspar, Ricardo, et al.
Publicado: (2018)

Transient Lipid-Protein Structures and Selective Ganglioside Uptake During α-Synuclein-Lipid Co-aggregation
por: Gaspar, Ricardo, et al.
Publicado: (2021)

Membrane Lipid Co-Aggregation with α-Synuclein Fibrils
por: Hellstrand, Erik, et al.
Publicado: (2013)

Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells
por: Moree, Ben, et al.
Publicado: (2015)

Anomalous Salt Dependence Reveals an Interplay of Attractive and Repulsive Electrostatic Interactions in α-synuclein Fibril Formation
por: Gaspar, Ricardo, et al.
Publicado: (2020)

On the Cluster Formation of α-Synuclein Fibrils
por: Dubackic, Marija, et al.
Publicado: (2021)

Retardation of Aβ42 fibril formation by apolipoprotein A-I and recombinant HDL particles
por: Frankel, Rebecca, et al.
Publicado: (2023)

What’s to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?
por: Dunning, Christopher J.R., et al.
Publicado: (2013)

The Impact of N-terminal Acetylation of α-Synuclein on Phospholipid Membrane Binding and Fibril Structure
por: Iyer, Aditya, et al.
Publicado: (2016)

Interaction of the Molecular Chaperone DNAJB6 with Growing Amyloid-beta 42 (Aβ42) Aggregates Leads to Sub-stoichiometric Inhibition of Amyloid Formation
por: Månsson, Cecilia, et al.
Publicado: (2014)

α-Synuclein-induced deformation of small unilamellar vesicles
por: Makasewicz, Katarzyna, et al.
Publicado: (2022)

Cooperativity of α-Synuclein Binding to Lipid Membranes
por: Makasewicz, Katarzyna, et al.
Publicado: (2021)

Lipid Dynamics and Phase Transition within α-Synuclein Amyloid Fibrils
por: Galvagnion, Céline, et al.
Publicado: (2019)

On the Aggregation of Apolipoprotein A-I
por: Frankel, Rebecca, et al.
Publicado: (2022)

Immunotherapy in Parkinson’s Disease: Micromanaging Alpha-Synuclein Aggregation
por: George, Sonia, et al.
Publicado: (2015)

α-Synuclein Interaction with Lipid Bilayer Discs
por: Dubackic, Marija, et al.
Publicado: (2022)

Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy
por: Dai, Lijun, et al.
Publicado: (2021)

Optimization of a small molecule inhibitor of secondary nucleation in α-synuclein aggregation
por: Staats, Roxine, et al.
Publicado: (2023)

Self-Assembly in Ganglioside‒Phospholipid Systems: The Co-Existence of Vesicles, Micelles, and Discs
por: Mojumdar, Enamul Haque, et al.
Publicado: (2019)

Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN α5β1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION
por: Mould, A. Paul, et al.
Publicado: (2016)

The Maturational Refolding of the β-Hairpin Motif of Equine Infectious Anemia Virus Capsid Protein Extends Its Helix α1 at Capsid Assembly Locus
por: Chen, Kang, et al.
Publicado: (2013)

Single-vesicle intensity and colocalization fluorescence microscopy to study lipid vesicle fusion, fission, and lipid exchange
por: Andersson, Alexandra, et al.
Publicado: (2022)

Structural Characterization of Hsp12, the Heat Shock Protein from Saccharomyces cerevisiae, in Aqueous Solution Where It Is Intrinsically Disordered and in Detergent Micelles Where It Is Locally α-Helical
por: Singarapu, Kiran K., et al.
Publicado: (2011)

A helical LC3-interacting region mediates the interaction between the retroviral restriction factor Trim5α and mammalian autophagy-related ATG8 proteins
por: Keown, Jeremy R., et al.
Publicado: (2018)

α‐Synuclein: The Long Distance Runner
por: George, Sonia, et al.
Publicado: (2013)

T Cells Limit Accumulation of Aggregate Pathology Following Intrastriatal Injection of α-Synuclein Fibrils
por: George, Sonia, et al.
Publicado: (2021)

Monitoring α-synuclein aggregation
por: Estaun-Panzano, Juan, et al.
Publicado: (2023)

Novel Mannitol-Based Small Molecules for Inhibiting Aggregation of α-Synuclein Amyloids in Parkinson's Disease
por: Paul, Ashim, et al.
Publicado: (2019)

The NPH-II Helicase Displays Efficient DNA·RNA Helicase Activity and a Pronounced Purine Sequence Bias
por: Taylor, Sean David, et al.
Publicado: (2010)

Editorial: Targeting α-Synuclein in Parkinson's Disease and Multiple System Atrophy
por: Fellner, Lisa, et al.
Publicado: (2022)

Molecular basis for N-terminal alpha-synuclein acetylation by human NatB
por: Deng, Sunbin, et al.
Publicado: (2020)

Characterization of the Biochemical Properties and Biological Function of the Formin Homology Domains of Drosophila DAAM
por: Barkó, Szilvia, et al.
Publicado: (2010)

Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces
por: Tesei, Giulio, et al.
Publicado: (2017)

Relationship between Prion Propensity and the Rates of Individual Molecular Steps of Fibril Assembly
por: Wang, Yi-Qian, et al.
Publicado: (2011)

Wild-Type α-Synuclein and Variants Occur in Different Disordered Dimers and Pre-Fibrillar Conformations in Early Stage of Aggregation
por: Guzzo , Adrien, et al.
Publicado: (2022)

The Aggregation of Huntingtin and α-Synuclein
por: Chánez-Cárdenas, María Elena, et al.
Publicado: (2012)

Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
por: Staats, Roxine, et al.
Publicado: (2020)

Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates
por: Chia, Sean, et al.
Publicado: (2022)

Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term
por: Rey, Nolwen L., et al.
Publicado: (2017)

Unveiling a Selective Mechanism for the Inhibition of α-Synuclein Aggregation by β-Synuclein
por: Leitao, Andre, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_amr9f8i0f8s3fpra7pp2516sou