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A novel application of t-statistics to objectively assess the quality of IC(50) fits for P-glycoprotein and other transporters

Current USFDA and EMA guidance for drug transporter interactions is dependent on IC(50) measurements as these are utilized in determining whether a clinical interaction study is warranted. It is therefore important not only to standardize transport inhibition assay systems but also to develop unifor...

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Detalles Bibliográficos
Autores principales:	O'Connor, Michael, Lee, Caroline, Ellens, Harma, Bentz, Joe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317220/ https://www.ncbi.nlm.nih.gov/pubmed/25692007 http://dx.doi.org/10.1002/prp2.78

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