Gene expression changes caused by the p38 MAPK inhibitor dilmapimod in COPD patients: analysis of blood and sputum samples from a randomized, placebo-controlled clinical trial

The p38 mitogen-activated protein kinase (MAPK) intracellular signaling pathway responds to a variety of extracellular stimuli, including cytokines, Toll-like receptor agonists, and components of cigarette smoke to influence the expression of proinflammatory mediators. Activation of p38 MAPK is incr...

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Detalles Bibliográficos
Autores principales: Betts, Joanna C, Mayer, Ruth J, Tal-Singer, Ruth, Warnock, Linda, Clayton, Chris, Bates, Stewart, Hoffman, Bryan E, Larminie, Christopher, Singh, Dave
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317226/
https://www.ncbi.nlm.nih.gov/pubmed/25692013
http://dx.doi.org/10.1002/prp2.94

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317226/
https://www.ncbi.nlm.nih.gov/pubmed/25692013
http://dx.doi.org/10.1002/prp2.94

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