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Active surveillance of visual impairment due to adverse drug reactions: findings from a national study in the United Kingdom
As visual impairment (VI) due to adverse drug reactions (ADR) is rare in adults and children, there is an incomplete evidence base to inform guidance for screening and for counseling patients on the potential risks of medications. We report on suspected drugs and the eye conditions found in a nation...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317237/ https://www.ncbi.nlm.nih.gov/pubmed/25692024 http://dx.doi.org/10.1002/prp2.107 |
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author | Cumberland, Phillippa M Russell-Eggitt, Isabelle Rahi, Jugnoo S |
author_facet | Cumberland, Phillippa M Russell-Eggitt, Isabelle Rahi, Jugnoo S |
author_sort | Cumberland, Phillippa M |
collection | PubMed |
description | As visual impairment (VI) due to adverse drug reactions (ADR) is rare in adults and children, there is an incomplete evidence base to inform guidance for screening and for counseling patients on the potential risks of medications. We report on suspected drugs and the eye conditions found in a national study of incidence of diagnosis of visual impairment due to suspected ADR. Case ascertainment was via the British Ophthalmological Surveillance Unit (BOSU), between March 2010 and February 2012, with follow-up after 6 months. Case definition: any child or adult with bilateral or unilateral visual impairment due to a suspected ADR, using distance acuity worse than Snellen 6/18 (logMAR 0.48) in the better eye (bilateral) or affected eye (unilateral). Anonymized patient information on potential cases was provided by managing ophthalmologists, comprising visual status before and after suspected ADR, ophthalmic condition attributable to the ADR, preexisting eye disease and prescribed medications at the time of the ADR. Permanency and causality of the visual impairment were confirmed by the managing clinician, after 6 months, using the WHO Uppsala Monitoring Committee criteria. Over 2 years, 36 eligible cases were reported of whom 23 had permanent VI. While most cases were due to drugs known to have adverse side-effects, some were unanticipated sporadic cases. Visual impairment due to ADRs is rare. However, with for example, increasing polypharmacy in the elderly, monitoring of ocular ADRs, although challenging, is necessary. |
format | Online Article Text |
id | pubmed-4317237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BlackWell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43172372015-02-17 Active surveillance of visual impairment due to adverse drug reactions: findings from a national study in the United Kingdom Cumberland, Phillippa M Russell-Eggitt, Isabelle Rahi, Jugnoo S Pharmacol Res Perspect Original Articles As visual impairment (VI) due to adverse drug reactions (ADR) is rare in adults and children, there is an incomplete evidence base to inform guidance for screening and for counseling patients on the potential risks of medications. We report on suspected drugs and the eye conditions found in a national study of incidence of diagnosis of visual impairment due to suspected ADR. Case ascertainment was via the British Ophthalmological Surveillance Unit (BOSU), between March 2010 and February 2012, with follow-up after 6 months. Case definition: any child or adult with bilateral or unilateral visual impairment due to a suspected ADR, using distance acuity worse than Snellen 6/18 (logMAR 0.48) in the better eye (bilateral) or affected eye (unilateral). Anonymized patient information on potential cases was provided by managing ophthalmologists, comprising visual status before and after suspected ADR, ophthalmic condition attributable to the ADR, preexisting eye disease and prescribed medications at the time of the ADR. Permanency and causality of the visual impairment were confirmed by the managing clinician, after 6 months, using the WHO Uppsala Monitoring Committee criteria. Over 2 years, 36 eligible cases were reported of whom 23 had permanent VI. While most cases were due to drugs known to have adverse side-effects, some were unanticipated sporadic cases. Visual impairment due to ADRs is rare. However, with for example, increasing polypharmacy in the elderly, monitoring of ocular ADRs, although challenging, is necessary. BlackWell Publishing Ltd 2015-02 2014-12-16 /pmc/articles/PMC4317237/ /pubmed/25692024 http://dx.doi.org/10.1002/prp2.107 Text en © 2014 The Authors. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Cumberland, Phillippa M Russell-Eggitt, Isabelle Rahi, Jugnoo S Active surveillance of visual impairment due to adverse drug reactions: findings from a national study in the United Kingdom |
title | Active surveillance of visual impairment due to adverse drug reactions: findings from a national study in the United Kingdom |
title_full | Active surveillance of visual impairment due to adverse drug reactions: findings from a national study in the United Kingdom |
title_fullStr | Active surveillance of visual impairment due to adverse drug reactions: findings from a national study in the United Kingdom |
title_full_unstemmed | Active surveillance of visual impairment due to adverse drug reactions: findings from a national study in the United Kingdom |
title_short | Active surveillance of visual impairment due to adverse drug reactions: findings from a national study in the United Kingdom |
title_sort | active surveillance of visual impairment due to adverse drug reactions: findings from a national study in the united kingdom |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317237/ https://www.ncbi.nlm.nih.gov/pubmed/25692024 http://dx.doi.org/10.1002/prp2.107 |
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