The Role of TREM2 in Alzheimer’s Disease and Other Neurological Disorders

Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Late-onset AD (LOAD), is the most common form of Alzheimer’s disease, representing about >95% of cases and early-onset AD represents <5% of cases. Several risk factors have been discovered that are associated with AD, with ad...

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Detalles Bibliográficos
Autores principales: Yaghmoor, Faris, Noorsaeed, Ahmed, Alsaggaf, Samar, Aljohani, Waleed, Scholtzova, Henrieta, Boutajangout, Allal, Wisniewski, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317331/
https://www.ncbi.nlm.nih.gov/pubmed/25664220
http://dx.doi.org/10.4172/2161-0460.1000160
Descripción
Sumario:Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Late-onset AD (LOAD), is the most common form of Alzheimer’s disease, representing about >95% of cases and early-onset AD represents <5% of cases. Several risk factors have been discovered that are associated with AD, with advancing age being the most prominent. Other environmental risk factors include diabetes mellitus, level of physical activity, educational status, hypertension and head injury. The most well known genetic risk factor for LOAD is inheritance of the apolipoprotein (apo) E4 allele. Recently, rare variants of TREM2 have been reported as a significant risk factor for LOAD, comparable to inheritance of apoE4. In this review we will focus on the role(s) of TREM2 in AD as well as in other neurodegenerative disorders.

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