The Role of TREM2 in Alzheimer’s Disease and Other Neurological Disorders

Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Late-onset AD (LOAD), is the most common form of Alzheimer’s disease, representing about >95% of cases and early-onset AD represents <5% of cases. Several risk factors have been discovered that are associated with AD, with ad...

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Autores principales: Yaghmoor, Faris, Noorsaeed, Ahmed, Alsaggaf, Samar, Aljohani, Waleed, Scholtzova, Henrieta, Boutajangout, Allal, Wisniewski, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317331/
https://www.ncbi.nlm.nih.gov/pubmed/25664220
http://dx.doi.org/10.4172/2161-0460.1000160
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author Yaghmoor, Faris
Noorsaeed, Ahmed
Alsaggaf, Samar
Aljohani, Waleed
Scholtzova, Henrieta
Boutajangout, Allal
Wisniewski, Thomas
author_facet Yaghmoor, Faris
Noorsaeed, Ahmed
Alsaggaf, Samar
Aljohani, Waleed
Scholtzova, Henrieta
Boutajangout, Allal
Wisniewski, Thomas
author_sort Yaghmoor, Faris
collection PubMed
description Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Late-onset AD (LOAD), is the most common form of Alzheimer’s disease, representing about >95% of cases and early-onset AD represents <5% of cases. Several risk factors have been discovered that are associated with AD, with advancing age being the most prominent. Other environmental risk factors include diabetes mellitus, level of physical activity, educational status, hypertension and head injury. The most well known genetic risk factor for LOAD is inheritance of the apolipoprotein (apo) E4 allele. Recently, rare variants of TREM2 have been reported as a significant risk factor for LOAD, comparable to inheritance of apoE4. In this review we will focus on the role(s) of TREM2 in AD as well as in other neurodegenerative disorders.
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spelling pubmed-43173312015-02-05 The Role of TREM2 in Alzheimer’s Disease and Other Neurological Disorders Yaghmoor, Faris Noorsaeed, Ahmed Alsaggaf, Samar Aljohani, Waleed Scholtzova, Henrieta Boutajangout, Allal Wisniewski, Thomas J Alzheimers Dis Parkinsonism Article Alzheimer’s disease (AD) is the leading cause of dementia worldwide. Late-onset AD (LOAD), is the most common form of Alzheimer’s disease, representing about >95% of cases and early-onset AD represents <5% of cases. Several risk factors have been discovered that are associated with AD, with advancing age being the most prominent. Other environmental risk factors include diabetes mellitus, level of physical activity, educational status, hypertension and head injury. The most well known genetic risk factor for LOAD is inheritance of the apolipoprotein (apo) E4 allele. Recently, rare variants of TREM2 have been reported as a significant risk factor for LOAD, comparable to inheritance of apoE4. In this review we will focus on the role(s) of TREM2 in AD as well as in other neurodegenerative disorders. 2014-10-06 2014-11 /pmc/articles/PMC4317331/ /pubmed/25664220 http://dx.doi.org/10.4172/2161-0460.1000160 Text en Copyright: © 2014 Yaghmoor F, et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Yaghmoor, Faris
Noorsaeed, Ahmed
Alsaggaf, Samar
Aljohani, Waleed
Scholtzova, Henrieta
Boutajangout, Allal
Wisniewski, Thomas
The Role of TREM2 in Alzheimer’s Disease and Other Neurological Disorders
title The Role of TREM2 in Alzheimer’s Disease and Other Neurological Disorders
title_full The Role of TREM2 in Alzheimer’s Disease and Other Neurological Disorders
title_fullStr The Role of TREM2 in Alzheimer’s Disease and Other Neurological Disorders
title_full_unstemmed The Role of TREM2 in Alzheimer’s Disease and Other Neurological Disorders
title_short The Role of TREM2 in Alzheimer’s Disease and Other Neurological Disorders
title_sort role of trem2 in alzheimer’s disease and other neurological disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317331/
https://www.ncbi.nlm.nih.gov/pubmed/25664220
http://dx.doi.org/10.4172/2161-0460.1000160
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