UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α

Hypoxia-inducible factor 1 (HIF-1) plays a role in tumour metastases; however, the genes that activate HIF-1 and subsequently promote metastases have yet to be identified. Here we show that Ubiquitin C-terminal hydrolase-L1 (UCHL1) abrogates the von Hippel–Lindau-mediated ubiquitination of HIF-1α, t...

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Detalles Bibliográficos
Autores principales: Goto, Yoko, Zeng, Lihua, Yeom, Chan Joo, Zhu, Yuxi, Morinibu, Akiyo, Shinomiya, Kazumi, Kobayashi, Minoru, Hirota, Kiichi, Itasaka, Satoshi, Yoshimura, Michio, Tanimoto, Keiji, Torii, Masae, Sowa, Terumasa, Menju, Toshi, Sonobe, Makoto, Kakeya, Hideaki, Toi, Masakazu, Date, Hiroshi, Hammond, Ester M., Hiraoka, Masahiro, Harada, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317501/
https://www.ncbi.nlm.nih.gov/pubmed/25615526
http://dx.doi.org/10.1038/ncomms7153

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