A concise synthesis of Fingolimod: an orally available drug for treating multiple sclerosis

A concise route for the synthesis of Fingolimod is reported. Starting from n-octylbenzene and 3-nitropropionic acid, a sequence of reactions consisting of Friedel-Crafts acylation, reduction, and double Henry reaction, followed by hydrogenation were applied to prepare Fingolimod with a yield of 31%,...

Descripción completa

Detalles Bibliográficos
Autores principales: Yan, Ning, Chen, Kai, Bai, Xinfa, Bi, Lei, Yao, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Preliminary Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317520/
https://www.ncbi.nlm.nih.gov/pubmed/25657817
http://dx.doi.org/10.1186/s13065-015-0081-8
Descripción
Sumario:A concise route for the synthesis of Fingolimod is reported. Starting from n-octylbenzene and 3-nitropropionic acid, a sequence of reactions consisting of Friedel-Crafts acylation, reduction, and double Henry reaction, followed by hydrogenation were applied to prepare Fingolimod with a yield of 31%, and an overall atom economy of 82.7%. [Figure: see text]

Ejemplares similares