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Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort Study
Between June 2010 and June 2011, 176 patients were divided into 2 groups: a group with spinal metastasis of solid tumors (n = 157) and a group with multiple myeloma (n = 19). Both groups were further divided into 2 subgroups: a group receiving zoledronic acid before surgery and a control group. The...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317594/ https://www.ncbi.nlm.nih.gov/pubmed/25685817 http://dx.doi.org/10.1155/2015/936307 |
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author | Wu, Juan Zheng, Wei Tan, Yan Hu, Xiao-Yuan Huang, Quan Fan, Kai-Hua Ma, Jie Xiao, Wen-Jing Ren, Jian-Dong Hou, Jun Xiao, Jian-Ru |
author_facet | Wu, Juan Zheng, Wei Tan, Yan Hu, Xiao-Yuan Huang, Quan Fan, Kai-Hua Ma, Jie Xiao, Wen-Jing Ren, Jian-Dong Hou, Jun Xiao, Jian-Ru |
author_sort | Wu, Juan |
collection | PubMed |
description | Between June 2010 and June 2011, 176 patients were divided into 2 groups: a group with spinal metastasis of solid tumors (n = 157) and a group with multiple myeloma (n = 19). Both groups were further divided into 2 subgroups: a group receiving zoledronic acid before surgery and a control group. The zoledronic acid subgroup of the solid tumors group was group A (n = 81), the control subgroup of the solid tumors group was group B (n = 76), the zoledronic acid subgroup of the multiple myeloma group was group C (n = 10), and the control subgroup of the multiple myeloma group was group D (n = 9). The average intraoperative blood loss during spinal surgery was as follows: 1311 ± 691 mL in group A and 1752 ± 740 mL in group B (P = 0.000) and 1994 ± 810 mL in group C and 3134 ± 795 mL in group D (P = 0.000). Patients receiving zoledronic acid before surgery had significantly less intraoperative bleeding than those who did not receive it. Preoperative use of zoledronic acid can effectively reduce intraoperative bleeding during surgery for the treatment of spinal tumors. |
format | Online Article Text |
id | pubmed-4317594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43175942015-02-15 Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort Study Wu, Juan Zheng, Wei Tan, Yan Hu, Xiao-Yuan Huang, Quan Fan, Kai-Hua Ma, Jie Xiao, Wen-Jing Ren, Jian-Dong Hou, Jun Xiao, Jian-Ru Biomed Res Int Clinical Study Between June 2010 and June 2011, 176 patients were divided into 2 groups: a group with spinal metastasis of solid tumors (n = 157) and a group with multiple myeloma (n = 19). Both groups were further divided into 2 subgroups: a group receiving zoledronic acid before surgery and a control group. The zoledronic acid subgroup of the solid tumors group was group A (n = 81), the control subgroup of the solid tumors group was group B (n = 76), the zoledronic acid subgroup of the multiple myeloma group was group C (n = 10), and the control subgroup of the multiple myeloma group was group D (n = 9). The average intraoperative blood loss during spinal surgery was as follows: 1311 ± 691 mL in group A and 1752 ± 740 mL in group B (P = 0.000) and 1994 ± 810 mL in group C and 3134 ± 795 mL in group D (P = 0.000). Patients receiving zoledronic acid before surgery had significantly less intraoperative bleeding than those who did not receive it. Preoperative use of zoledronic acid can effectively reduce intraoperative bleeding during surgery for the treatment of spinal tumors. Hindawi Publishing Corporation 2015 2015-01-22 /pmc/articles/PMC4317594/ /pubmed/25685817 http://dx.doi.org/10.1155/2015/936307 Text en Copyright © 2015 Juan Wu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Wu, Juan Zheng, Wei Tan, Yan Hu, Xiao-Yuan Huang, Quan Fan, Kai-Hua Ma, Jie Xiao, Wen-Jing Ren, Jian-Dong Hou, Jun Xiao, Jian-Ru Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort Study |
title | Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort Study |
title_full | Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort Study |
title_fullStr | Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort Study |
title_full_unstemmed | Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort Study |
title_short | Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort Study |
title_sort | zoledronic acid may reduce intraoperative bleeding in spinal tumors: a prospective cohort study |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317594/ https://www.ncbi.nlm.nih.gov/pubmed/25685817 http://dx.doi.org/10.1155/2015/936307 |
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